Effects of intravenous ranitidine and esomeprazole on gastric PH and volume in patients undergoing emergency appendicectomy

Research output: Contribution to journalArticle

Abstract

Introduction: Pulmonary aspiration of gastric contents is a potentially life threatening complication of general anaesthesia especially in high risk patients undergoing emergency anaesthesia. Classically, ranitidine has been used to reduce gastric pH and volume. Esomeprazole, the S-isomer of omeprazole, is a newer generation proton pump inhibitor whose effect on gastric pH and volume in emergency surgeries has not been determined. Materials and Methods: This was a prospective, randomised, double blind study to compare the effect of intravenous esomeprazole and ranitidine on gastric pH and volume in patients undergoing emergency appendicectomy. Following induction of anaesthesia, seventy patients of American Society of Anesthesiologists physical status I or II had their gastric contents aspirated via a nasogastric tube. They were then randomised to receive either intravenous esomeprazole 40 mg or intravenous ranitidine 50 mg. A second aspiration of gastric contents was done three hours later. The pH and volume of gastric contents of both aspirations were recorded. Results: Both intravenous esomeprazole and ranitidine significantly reduced the gastric fluid acidity (p=0.001) and volume (p=0.001). There were no significant differences measured between the two groups in terms of gastric fluid pH (p=0.86) and gastric fluid volume (p=0.14) after administration of study drugs. Conclusion: Esomeprazole and ranitidine given intravenously were both comparable in reducing the volume and acidity of gastric secretions in patients undergoing emergency appendicectomy.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalBrunei International Medical Journal
Volume8
Issue number6
Publication statusPublished - Dec 2012

Fingerprint

Esomeprazole
Ranitidine
Stomach
Emergencies
Gastrointestinal Contents
Anesthesia
Omeprazole
Proton Pump Inhibitors
Double-Blind Method
General Anesthesia
Lung

Keywords

  • Acid suppression therapy
  • Appendicectomy
  • Esomeprazole
  • Pulmonary aspiration
  • Ranitidine

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Effects of intravenous ranitidine and esomeprazole on gastric PH and volume in patients undergoing emergency appendicectomy",
abstract = "Introduction: Pulmonary aspiration of gastric contents is a potentially life threatening complication of general anaesthesia especially in high risk patients undergoing emergency anaesthesia. Classically, ranitidine has been used to reduce gastric pH and volume. Esomeprazole, the S-isomer of omeprazole, is a newer generation proton pump inhibitor whose effect on gastric pH and volume in emergency surgeries has not been determined. Materials and Methods: This was a prospective, randomised, double blind study to compare the effect of intravenous esomeprazole and ranitidine on gastric pH and volume in patients undergoing emergency appendicectomy. Following induction of anaesthesia, seventy patients of American Society of Anesthesiologists physical status I or II had their gastric contents aspirated via a nasogastric tube. They were then randomised to receive either intravenous esomeprazole 40 mg or intravenous ranitidine 50 mg. A second aspiration of gastric contents was done three hours later. The pH and volume of gastric contents of both aspirations were recorded. Results: Both intravenous esomeprazole and ranitidine significantly reduced the gastric fluid acidity (p=0.001) and volume (p=0.001). There were no significant differences measured between the two groups in terms of gastric fluid pH (p=0.86) and gastric fluid volume (p=0.14) after administration of study drugs. Conclusion: Esomeprazole and ranitidine given intravenously were both comparable in reducing the volume and acidity of gastric secretions in patients undergoing emergency appendicectomy.",
keywords = "Acid suppression therapy, Appendicectomy, Esomeprazole, Pulmonary aspiration, Ranitidine",
author = "{Pg Naidu}, {Komala Devi} and {Wan Mat}, {Wan Rahiza} and {Abdul Rahman}, Raha and {Abdul Manap}, Norsidah and Liu, {Chian Yong} and Nurlia Yahya",
year = "2012",
month = "12",
language = "English",
volume = "8",
pages = "342--348",
journal = "Brunei International Medical Journal",
issn = "1560-5876",
publisher = "Ministry of Health and Universiti Brunei Darussalem",
number = "6",

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TY - JOUR

T1 - Effects of intravenous ranitidine and esomeprazole on gastric PH and volume in patients undergoing emergency appendicectomy

AU - Pg Naidu, Komala Devi

AU - Wan Mat, Wan Rahiza

AU - Abdul Rahman, Raha

AU - Abdul Manap, Norsidah

AU - Liu, Chian Yong

AU - Yahya, Nurlia

PY - 2012/12

Y1 - 2012/12

N2 - Introduction: Pulmonary aspiration of gastric contents is a potentially life threatening complication of general anaesthesia especially in high risk patients undergoing emergency anaesthesia. Classically, ranitidine has been used to reduce gastric pH and volume. Esomeprazole, the S-isomer of omeprazole, is a newer generation proton pump inhibitor whose effect on gastric pH and volume in emergency surgeries has not been determined. Materials and Methods: This was a prospective, randomised, double blind study to compare the effect of intravenous esomeprazole and ranitidine on gastric pH and volume in patients undergoing emergency appendicectomy. Following induction of anaesthesia, seventy patients of American Society of Anesthesiologists physical status I or II had their gastric contents aspirated via a nasogastric tube. They were then randomised to receive either intravenous esomeprazole 40 mg or intravenous ranitidine 50 mg. A second aspiration of gastric contents was done three hours later. The pH and volume of gastric contents of both aspirations were recorded. Results: Both intravenous esomeprazole and ranitidine significantly reduced the gastric fluid acidity (p=0.001) and volume (p=0.001). There were no significant differences measured between the two groups in terms of gastric fluid pH (p=0.86) and gastric fluid volume (p=0.14) after administration of study drugs. Conclusion: Esomeprazole and ranitidine given intravenously were both comparable in reducing the volume and acidity of gastric secretions in patients undergoing emergency appendicectomy.

AB - Introduction: Pulmonary aspiration of gastric contents is a potentially life threatening complication of general anaesthesia especially in high risk patients undergoing emergency anaesthesia. Classically, ranitidine has been used to reduce gastric pH and volume. Esomeprazole, the S-isomer of omeprazole, is a newer generation proton pump inhibitor whose effect on gastric pH and volume in emergency surgeries has not been determined. Materials and Methods: This was a prospective, randomised, double blind study to compare the effect of intravenous esomeprazole and ranitidine on gastric pH and volume in patients undergoing emergency appendicectomy. Following induction of anaesthesia, seventy patients of American Society of Anesthesiologists physical status I or II had their gastric contents aspirated via a nasogastric tube. They were then randomised to receive either intravenous esomeprazole 40 mg or intravenous ranitidine 50 mg. A second aspiration of gastric contents was done three hours later. The pH and volume of gastric contents of both aspirations were recorded. Results: Both intravenous esomeprazole and ranitidine significantly reduced the gastric fluid acidity (p=0.001) and volume (p=0.001). There were no significant differences measured between the two groups in terms of gastric fluid pH (p=0.86) and gastric fluid volume (p=0.14) after administration of study drugs. Conclusion: Esomeprazole and ranitidine given intravenously were both comparable in reducing the volume and acidity of gastric secretions in patients undergoing emergency appendicectomy.

KW - Acid suppression therapy

KW - Appendicectomy

KW - Esomeprazole

KW - Pulmonary aspiration

KW - Ranitidine

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