Effects of Gynura procumbens on sperm quality and testosterone level in streptozotocin-induced type 1 diabetic rats

H. Pusparanee, H. W. Lee, A. S. Halimah, Mahanem Mat Noor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Diabetes mellitus have been shown to bring about deteriorating effects on the male reproductive system due to increased oxidative stress. Gynura procumbens, an herb with known anti-diabetic properties, was used in this investigation to determine the effect of its aqueous and ethanolic extracts on sperm quality and testosterone level of male streptozotocin-induced Type 1 diabetic rats. Metformin and glibenclamide were used as control drugs in this study. Diabetic rats force-fed with 150 mg/kg of ethanolic G. procumbens extract showed dramatic increase in sperm count (206.89%) and motility as well as testosterone level (16.71%), along with decrease in fasting blood glucose level (38.71%) and sperm mortality (57.62%) when compared to the controls. Treatment with aqueous G. procumbens extract showed similar results with 23.38% and 31.14% decrease in blood glucose level and sperm mortality respectively, coupled with improvement in testosterone level (8.60%), sperm count (124.79%) and motility. The present data indicate that traditional use of G. procumbens as an anti-hyperglycemic agent is justified and may be beneficial for male diabetic patients that suffer from sexual dysfunction as a side effect of prolonged hyperglycemia seen in Type 1 diabetic patients.

Original languageEnglish
Pages (from-to)22-30
Number of pages9
JournalInternational Journal of Pharmacognosy and Phytochemical Research
Volume8
Issue number1
Publication statusPublished - 1 Jan 2016

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Streptozocin
Testosterone
Spermatozoa
Sperm Count
Sperm Motility
Blood Glucose
Mortality
Glyburide
Metformin
Drug and Narcotic Control
Hyperglycemia
Fasting
Diabetes Mellitus
Oxidative Stress
Therapeutics

Keywords

  • Diabetes mellitus type 1
  • Gynura procumbens
  • Sperm quality
  • Testosterone

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Effects of Gynura procumbens on sperm quality and testosterone level in streptozotocin-induced type 1 diabetic rats. / Pusparanee, H.; Lee, H. W.; Halimah, A. S.; Mat Noor, Mahanem.

In: International Journal of Pharmacognosy and Phytochemical Research, Vol. 8, No. 1, 01.01.2016, p. 22-30.

Research output: Contribution to journalArticle

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