Kesan Gynura procumbens terhadap integriti DNA dan kualiti sperma mencit

Translated title of the contribution: Effects of Gynura procumbens on DNA integrity and sperm quality of mice

Emynurshiela Anuar, Umarqayum Abu Bakar, Mahanem Mat Noor

Research output: Contribution to journalArticle

Abstract

Issues of male infertility are growing and currently, there are no successful treatments were able to overcome it. Gynura procumbens is a type of herbal plant that might has a potential to treat this problem. There are previous increase in the number and motility of sperm when G. procumbens was consumed as a diet, however the effect of G. procumbens on the integrity of sperm DNA is still unknown. Therefore, this study was aimed to evaluate the effect of G. procumbens extract on the DNA integrity and quality of sperm from male mice. Four groups of mice were force fed with G. procumbens extract (100, 200 and 300 mg/mL) and distilled water for a continuously 28 days. All doses of G. procumbens and control showed that characteristics of the sperm DNA were normal and the percentage of intact DNA in the sperm head were above 92%. All treatments with G. procumbens exhibited significant (p<0.05) increase in the number of sperm count compared to control, (8.14 ± 1.06) × 106 and treatment with 300 mg/mL exhibited the highest of sperm count (16.54 ± 3.2) × 106. The percentage of progressive motility of the sperm from this group was also the highest (49.52%) compared to control (27.7%) and exhibited a complete spermatogenic cell’s developmental phases. In conclusion, this study clearly demonstrated that G. procumbens extract did not cause DNA damage for the sperm and a few male fertility parameters were improved.

Original languageMalay
Pages (from-to)1991-1997
Number of pages7
JournalSains Malaysiana
Volume47
Issue number9
DOIs
Publication statusPublished - 1 Jan 2018

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Gynura procumbens
spermatozoa
mice
DNA
male fertility
sperm motility
extracts
DNA damage

ASJC Scopus subject areas

  • General

Cite this

Kesan Gynura procumbens terhadap integriti DNA dan kualiti sperma mencit. / Anuar, Emynurshiela; Bakar, Umarqayum Abu; Mat Noor, Mahanem.

In: Sains Malaysiana, Vol. 47, No. 9, 01.01.2018, p. 1991-1997.

Research output: Contribution to journalArticle

Anuar, Emynurshiela ; Bakar, Umarqayum Abu ; Mat Noor, Mahanem. / Kesan Gynura procumbens terhadap integriti DNA dan kualiti sperma mencit. In: Sains Malaysiana. 2018 ; Vol. 47, No. 9. pp. 1991-1997.
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