Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats

Ruszymah Idrus, Nabishah Mohamad, S. Aminuddin, B. A K Khalid

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16 Citations (Scopus)

Abstract

Glycyrrhizic acid (GCA) the active component of liquorice acts by inhibiting 11ßhydroxysteroid dehydrogenase (11ßOHSD) which catalyses the reversible conversion of cortisol to cortisone. The aim of this study was to examine the effect of GCA on pulmonary arterial pressure. Male Sprague-Dawley rats (200g) received drinking water containing 0.1 mg/ml and 1.0 mg/ml GCA for 12 weeks. Tail blood pressure (BP) was recorded every three weeks and serum Na+ and K+ were measured at the begining and the end of the experiment. Right atrial pressure (RAP) were measured at the end of 12 weeks just before the animals were sacrificed. Lung tissues were taken for histological examination using the elastic-van Gieson (EVG) staining method. There was a significant increase in tail BP in GCA treated rats compared to controls, for both dosages used. This was associated with an increase in serum Na+ and a decrease in K+ level. The mean RAP increased significantly from 2.69 ± 0.23 mmHg to 4.47 ± 0.32 mmHg (P<0.001) in 0.1 mg/ml GCA treated rats and 6.86 ± 0.54 mmHg (P<0.0001) in rats receiving 1.0 mg/ml GCA in their drinking water. Histological examination showed increased thickness of pulmonary arterial wall (P<0.000l). In conclusion GCA caused an increase in right atrial pressure as well as thickening of the pulmonary vessels suggesting pulmonary hypertension.

Original languageEnglish
Pages (from-to)575-591
Number of pages17
JournalClinical and Experimental Hypertension
Volume17
Issue number3
DOIs
Publication statusPublished - 1995

Fingerprint

Glycyrrhizic Acid
Atrial Pressure
Lung
Drinking Water
Tail
Blood Pressure
Glycyrrhiza
Cortisone
Serum
Pulmonary Hypertension
Sprague Dawley Rats
Hydrocortisone
Arterial Pressure
Oxidoreductases
Staining and Labeling

Keywords

  • Glycyrrhizic acid
  • Hypertension
  • Lung

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Effects of glycyrrhizic acid on right atrial pressure and pulmonary vasculature in rats. / Idrus, Ruszymah; Mohamad, Nabishah; Aminuddin, S.; Khalid, B. A K.

In: Clinical and Experimental Hypertension, Vol. 17, No. 3, 1995, p. 575-591.

Research output: Contribution to journalArticle

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