Effects of eurycoma longifolia on callous strength of male osteoporosis fracture model

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Abstract

Eurycoma longifolia (EL), a medicinal plant with pro-androgenic effects was recently reported to possess anti-osteoporotic activities. However, its effect on osteoporotic fracture has never been studied. This study aimed to provide more insight into the action of EL on healing of osteoporotic fracture by assessing callous strength. Tibial fracture was induced in orchidectomised rat, the model for osteoporotic fracture in androgen-deficiency state. The effects of EL supplementation for 6 weeks on fracture healing was assessed using Instron, a biomechanical testing device. The results were compared with testosterone, the standard treatment for androgen deficiency. Based on the biomechanical parameters, EL did not significantly improve the strength of fracture callous compared to testosterone replacement. These findings were not supportive of the role of EL in promoting osteoporotic fracture healing in orchidectomised rat model. To discover the true potential of EL, studies should be repeated with different castration models with intact testes for testosterone production.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalInternational Journal of Osteoporosis and Metabolic Disorders
Volume8
Issue number1
DOIs
Publication statusPublished - 21 Jul 2015

Fingerprint

Eurycoma
Osteoporosis
Osteoporotic Fractures
Testosterone
Fracture Healing
Androgens
Tibial Fractures
Castration
Medicinal Plants
Testis
Equipment and Supplies

Keywords

  • Biomechanical strength
  • Callous
  • Eurycoma longifolia androgen
  • Fracture
  • Orchidectomy
  • Osteoporosis

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism

Cite this

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title = "Effects of eurycoma longifolia on callous strength of male osteoporosis fracture model",
abstract = "Eurycoma longifolia (EL), a medicinal plant with pro-androgenic effects was recently reported to possess anti-osteoporotic activities. However, its effect on osteoporotic fracture has never been studied. This study aimed to provide more insight into the action of EL on healing of osteoporotic fracture by assessing callous strength. Tibial fracture was induced in orchidectomised rat, the model for osteoporotic fracture in androgen-deficiency state. The effects of EL supplementation for 6 weeks on fracture healing was assessed using Instron, a biomechanical testing device. The results were compared with testosterone, the standard treatment for androgen deficiency. Based on the biomechanical parameters, EL did not significantly improve the strength of fracture callous compared to testosterone replacement. These findings were not supportive of the role of EL in promoting osteoporotic fracture healing in orchidectomised rat model. To discover the true potential of EL, studies should be repeated with different castration models with intact testes for testosterone production.",
keywords = "Biomechanical strength, Callous, Eurycoma longifolia androgen, Fracture, Orchidectomy, Osteoporosis",
author = "J. Azri and Shuid, {Ahmad Nazrun} and Mokhtar, {Sabarul Afian} and {Mohd Fadli}, K. and Norliza Muhammad",
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AU - Shuid, Ahmad Nazrun

AU - Mokhtar, Sabarul Afian

AU - Mohd Fadli, K.

AU - Muhammad, Norliza

PY - 2015/7/21

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N2 - Eurycoma longifolia (EL), a medicinal plant with pro-androgenic effects was recently reported to possess anti-osteoporotic activities. However, its effect on osteoporotic fracture has never been studied. This study aimed to provide more insight into the action of EL on healing of osteoporotic fracture by assessing callous strength. Tibial fracture was induced in orchidectomised rat, the model for osteoporotic fracture in androgen-deficiency state. The effects of EL supplementation for 6 weeks on fracture healing was assessed using Instron, a biomechanical testing device. The results were compared with testosterone, the standard treatment for androgen deficiency. Based on the biomechanical parameters, EL did not significantly improve the strength of fracture callous compared to testosterone replacement. These findings were not supportive of the role of EL in promoting osteoporotic fracture healing in orchidectomised rat model. To discover the true potential of EL, studies should be repeated with different castration models with intact testes for testosterone production.

AB - Eurycoma longifolia (EL), a medicinal plant with pro-androgenic effects was recently reported to possess anti-osteoporotic activities. However, its effect on osteoporotic fracture has never been studied. This study aimed to provide more insight into the action of EL on healing of osteoporotic fracture by assessing callous strength. Tibial fracture was induced in orchidectomised rat, the model for osteoporotic fracture in androgen-deficiency state. The effects of EL supplementation for 6 weeks on fracture healing was assessed using Instron, a biomechanical testing device. The results were compared with testosterone, the standard treatment for androgen deficiency. Based on the biomechanical parameters, EL did not significantly improve the strength of fracture callous compared to testosterone replacement. These findings were not supportive of the role of EL in promoting osteoporotic fracture healing in orchidectomised rat model. To discover the true potential of EL, studies should be repeated with different castration models with intact testes for testosterone production.

KW - Biomechanical strength

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KW - Eurycoma longifolia androgen

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KW - Orchidectomy

KW - Osteoporosis

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