Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats

A. B. Kamis, R. A. Ahmad, Badrul Munir Md. Zain

Research output: Contribution to journalArticle

Abstract

Gonadectomized male laboratory rats were given 0.06 mg/kg estradiol benzoate daily for 14 days before being inoculated with 50 third-stage larvae of Parastrongylus malaysiensis. Hormone treatment was continued until the rats were killed. The numbers of larvae in the brain and of adult worms in the pulmonary area of the rats were determined every 7 days after the inoculation. It was found that the rats treated daily with estradiol benzoate had significantly and consistently higher numbers of larvae and adult worms as compared with the controls. The number of total leukocytes increased significantly after the rats were infected. The results show that estradiol-treated rats become susceptible to P. malaysiensis infection, which may indicate that the immunosuppressive effects of testosterone observed in earlier studies may partly be caused by estradiol that was peripherally aromatized from testosterone.

Original languageEnglish
Pages (from-to)74-77
Number of pages4
JournalParasitology Research
Volume80
Issue number1
DOIs
Publication statusPublished - Jan 1994

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Parastrongylus
estradiol
Estradiol
leukocytes
Leukocytes
rats
Larva
benzoates
testosterone
Testosterone
larvae
immunosuppressive agents
Immunosuppressive Agents
Leukocyte Count
lungs
hormones
Hormones
brain
Lung

ASJC Scopus subject areas

  • Parasitology

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Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats. / Kamis, A. B.; Ahmad, R. A.; Md. Zain, Badrul Munir.

In: Parasitology Research, Vol. 80, No. 1, 01.1994, p. 74-77.

Research output: Contribution to journalArticle

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