Effects of chalcone derivatives on players of the immune system

Jian Sian Lee, Bukhari Syed Nasir Abbas, Norsyahida Mohd Fauzi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The immune system is the defense mechanism in living organisms that protects against the invasion of foreign materials, microorganisms, and pathogens. It involves multiple organs and tissues in human body, such as lymph nodes, spleen, and mucosa-associated lymphoid tissues. However, the execution of immune activities depends on a number of specific cell types, such as B cells, T cells, macrophages, and granulocytes, which provide various immune responses against pathogens. In addition to normal physiological functions, abnormal proliferation, migration, and differentiation of these cells (in response to various chemical stimuli produced by invading pathogens) have been associated with several pathological disorders. The unwanted conditions related to these cells have made them prominent targets in the development of new therapeutic interventions against various pathological implications, such as atherosclerosis and autoimmune diseases. Chalcone derivatives exhibit a broad spectrum of pharmacological activities, such as immunomodulation, as well as anti-inflammatory, anticancer, antiviral, and antimicrobial properties. Many studies have been conducted to determine their inhibitory or stimulatory activities in immune cells, and the findings are of significance to provide a new direction for subsequent research. This review highlights the effects of chalcone derivatives in different types of immune cells.

Original languageEnglish
Pages (from-to)4761-4778
Number of pages18
JournalDrug Design, Development and Therapy
Volume9
DOIs
Publication statusPublished - 19 Aug 2015

Fingerprint

Chalcone
Immune System
Immunomodulation
Lymphoid Tissue
Human Body
Granulocytes
Autoimmune Diseases
Cell Movement
Antiviral Agents
Cell Differentiation
Atherosclerosis
Mucous Membrane
B-Lymphocytes
Anti-Inflammatory Agents
Spleen
Cell Count
Lymph Nodes
Macrophages
Pharmacology
T-Lymphocytes

Keywords

  • Macrophages
  • Neutrophils
  • T-cells

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Effects of chalcone derivatives on players of the immune system. / Lee, Jian Sian; Syed Nasir Abbas, Bukhari; Mohd Fauzi, Norsyahida.

In: Drug Design, Development and Therapy, Vol. 9, 19.08.2015, p. 4761-4778.

Research output: Contribution to journalArticle

Lee, Jian Sian ; Syed Nasir Abbas, Bukhari ; Mohd Fauzi, Norsyahida. / Effects of chalcone derivatives on players of the immune system. In: Drug Design, Development and Therapy. 2015 ; Vol. 9. pp. 4761-4778.
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