Effects of cassia alata treatment towards cardiovascular oxidative stress in hyperglycemic rats

Reezal Ishak, Izuddin Fahmy Abu, Haziqah Md Lajis, Kaswandi Md Ambia, Rahim Md Noah

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hyperglycemia induced oxidative stress has been proposed as a cause of many complications in diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of Cassia alata leaf aqueous extract on oxidative stress in aorta as well as heart of streptozotoc in hyperglycemic rats. Two days after diabetes induction, Cassia alata leaf aqueous extract was administered orally for 20 days (200mg/kg rat’s weight). In the aorta and heart of hyperglycemic rats there was a significant increase in lipid peroxidation, decreased in total antioxidant activity (DPPH free radical scavenging activity) as well as decrease in antioxidant catalase activity. The administration of Cassia alata leaf aqueous extract to hyperglycemic rats has reduced lipid peroxidation (MDA levels), increased in total antioxidant activity (DPPH free radical scavenging activity) and antioxidant catalase activity as well as reduced in the blood glucose level. Cassia alata leaf aqueous extract provide a competent antioxidative mechanism to attack against the oxidative stress in the aorta and heart of hyperglycemic rats. This study suggests that Cassia alata may be a useful therapeutic alternative in the reversal of oxidative stress induced cardiac dysfunction in hyperglycemic condition as well as capable to act as antidiabetic agent.

Original languageEnglish
Pages (from-to)254-258
Number of pages5
JournalInternational Journal of Pharmaceutical Sciences Review and Research
Volume34
Issue number2
Publication statusPublished - 1 Sep 2015
Externally publishedYes

Fingerprint

Cassia
Oxidative Stress
Antioxidants
Aorta
Catalase
Lipid Peroxidation
Free Radicals
Therapeutic Uses
Diabetes Complications
Hypoglycemic Agents
Hyperglycemia
Blood Glucose
Weights and Measures

Keywords

  • Antioxidant activity
  • Blood glucose level
  • Cassia alata
  • Hyperglycemic
  • Lipid peroxidation (MDA levels)

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effects of cassia alata treatment towards cardiovascular oxidative stress in hyperglycemic rats. / Ishak, Reezal; Abu, Izuddin Fahmy; Lajis, Haziqah Md; Ambia, Kaswandi Md; Noah, Rahim Md.

In: International Journal of Pharmaceutical Sciences Review and Research, Vol. 34, No. 2, 01.09.2015, p. 254-258.

Research output: Contribution to journalArticle

Ishak, Reezal ; Abu, Izuddin Fahmy ; Lajis, Haziqah Md ; Ambia, Kaswandi Md ; Noah, Rahim Md. / Effects of cassia alata treatment towards cardiovascular oxidative stress in hyperglycemic rats. In: International Journal of Pharmaceutical Sciences Review and Research. 2015 ; Vol. 34, No. 2. pp. 254-258.
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