Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats

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Abstract

Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production. Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes. Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity. This study was conducted to evaluate the effects of CO leaves aqueous extract on the blood glucose and T lymphocyte population in the spleen of streptozotocin (STZ)-induced diabetic rats. Nineteen male Sprague-Dawley rats were randomly divided into three groups: normal, diabetic control and CO treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of 65mg STZ/kg body weight. The extract of CO leaves was administered orally by force feeding daily at the dose of 300mg/kg for 28days. The rats were sacrificed at the end of the study and the spleen was harvested for flow cytometry analysis. The results showed a significant decrease in body weight of diabetic and CO treated diabetic groups compared with the normal group (p + CD4+ T lymphocytes (p + CD8+ T lymphocytes among all experimental groups. The finding suggested that an aqueous extract of CO leaves has the ability to reduce blood glucose levels in diabetic rats.

Original languageEnglish
JournalSaudi Journal of Biological Sciences
DOIs
Publication statusAccepted/In press - 1 May 2015

Fingerprint

Canarium odontophyllum
streptozotocin
Streptozocin
T-lymphocytes
T-Lymphocytes
Type 1 Diabetes Mellitus
Glucose
glucose
Blood Glucose
rats
Spleen
Body Weight
Population
leaves
insulin-dependent diabetes mellitus
Enteral Nutrition
Intraperitoneal Injections
blood glucose
Sprague Dawley Rats
Fruit

Keywords

  • Antioxidant activity
  • Canarium odontophyllum
  • Diabetic rats
  • Plasma glucose
  • Streptozotocin
  • T lymphocytes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

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title = "Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats",
abstract = "Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production. Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes. Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity. This study was conducted to evaluate the effects of CO leaves aqueous extract on the blood glucose and T lymphocyte population in the spleen of streptozotocin (STZ)-induced diabetic rats. Nineteen male Sprague-Dawley rats were randomly divided into three groups: normal, diabetic control and CO treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of 65mg STZ/kg body weight. The extract of CO leaves was administered orally by force feeding daily at the dose of 300mg/kg for 28days. The rats were sacrificed at the end of the study and the spleen was harvested for flow cytometry analysis. The results showed a significant decrease in body weight of diabetic and CO treated diabetic groups compared with the normal group (p + CD4+ T lymphocytes (p + CD8+ T lymphocytes among all experimental groups. The finding suggested that an aqueous extract of CO leaves has the ability to reduce blood glucose levels in diabetic rats.",
keywords = "Antioxidant activity, Canarium odontophyllum, Diabetic rats, Plasma glucose, Streptozotocin, T lymphocytes",
author = "Saari, {Shafikha Mohd} and Basri, {Dayang Fredalina} and Budin, {Siti Balkis} and {Abd Warif}, {Nor Malia}",
year = "2015",
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T1 - Effects of Canarium odontophyllum leaves on plasma glucose and T lymphocyte population in streptozotocin-induced diabetic rats

AU - Saari, Shafikha Mohd

AU - Basri, Dayang Fredalina

AU - Budin, Siti Balkis

AU - Abd Warif, Nor Malia

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production. Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes. Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity. This study was conducted to evaluate the effects of CO leaves aqueous extract on the blood glucose and T lymphocyte population in the spleen of streptozotocin (STZ)-induced diabetic rats. Nineteen male Sprague-Dawley rats were randomly divided into three groups: normal, diabetic control and CO treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of 65mg STZ/kg body weight. The extract of CO leaves was administered orally by force feeding daily at the dose of 300mg/kg for 28days. The rats were sacrificed at the end of the study and the spleen was harvested for flow cytometry analysis. The results showed a significant decrease in body weight of diabetic and CO treated diabetic groups compared with the normal group (p + CD4+ T lymphocytes (p + CD8+ T lymphocytes among all experimental groups. The finding suggested that an aqueous extract of CO leaves has the ability to reduce blood glucose levels in diabetic rats.

AB - Type 1 diabetes mellitus is a chronic disease characterized by lack of insulin production. Immune mechanisms are implicated in the pathogenesis of Type 1 diabetes. Canarium odontophyllum (CO) fruits and leaves have been shown to possess high antioxidant activity. This study was conducted to evaluate the effects of CO leaves aqueous extract on the blood glucose and T lymphocyte population in the spleen of streptozotocin (STZ)-induced diabetic rats. Nineteen male Sprague-Dawley rats were randomly divided into three groups: normal, diabetic control and CO treated diabetic groups. Diabetes was induced by a single intraperitoneal injection of 65mg STZ/kg body weight. The extract of CO leaves was administered orally by force feeding daily at the dose of 300mg/kg for 28days. The rats were sacrificed at the end of the study and the spleen was harvested for flow cytometry analysis. The results showed a significant decrease in body weight of diabetic and CO treated diabetic groups compared with the normal group (p + CD4+ T lymphocytes (p + CD8+ T lymphocytes among all experimental groups. The finding suggested that an aqueous extract of CO leaves has the ability to reduce blood glucose levels in diabetic rats.

KW - Antioxidant activity

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KW - T lymphocytes

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