Effects of calcium supplements on fracture healing in a rat osteoporotic model

Ahmad Nazrun Shuid, Sharlina Mohamad, Norazlina Mohamed, Fazalina Mohd. Fadzilah, Sabarul Afian Mokhtar, Shahrum Abdullah, Faizah Othman, Farihah Suhaimi, Norliza Muhammad, Ima Nirwana Soelaiman

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Fracture healing is a complex process, which is further complicated if the bone is osteoporotic. Calcium is one of the important minerals in bone and has been found to prevent osteoporosis but its role in fracture healing of osteoporotic bone is still unclear. We carried out a study on the effects of calcium supplementation on the late phase healing of fractured osteoporotic bone using an ovariectomized rat model. Twenty-four female Sprague-Dawley rats were divided into three groups: sham-operated (SO), ovariectomized-control (OVXC), and ovariectomized + calcium supplements (Ca). The right femurs of all the rats were fractured at mid-epiphysis and a K-wire was inserted for internal fixation. After 2 months of treatment, the rats were sacrificed and the femora were dissected out for radiological and biomechanical assessment. As expected, osteoporosis resulted in impaired healing as shown by the poor radiological and biomechanical properties of the OVXC group. CT scans showed significantly lower callus volumes in the SO and Ca groups compared to the OVXC group. Radiological scoring of fracture healing and callus staging of the SO and Ca groups were better than the OVXC group. However, the biomechanical parameters of the Ca group were significantly lower than the SO group and similar to the OVXC group. Therefore, calcium supplements may appear to improve fracture healing of osteoporotic bone but failed to improve strength.

Original languageEnglish
Pages (from-to)1651-1656
Number of pages6
JournalJournal of Orthopaedic Research
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2010

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Fracture Healing
Calcium
Bone and Bones
Bony Callus
Femur
Osteoporosis
Epiphyses
Minerals
Sprague Dawley Rats

Keywords

  • bone fracture
  • calcium
  • callus
  • osteoporosis
  • ovariectomy

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Effects of calcium supplements on fracture healing in a rat osteoporotic model. / Shuid, Ahmad Nazrun; Mohamad, Sharlina; Mohamed, Norazlina; Mohd. Fadzilah, Fazalina; Mokhtar, Sabarul Afian; Abdullah, Shahrum; Othman, Faizah; Suhaimi, Farihah; Muhammad, Norliza; Soelaiman, Ima Nirwana.

In: Journal of Orthopaedic Research, Vol. 28, No. 12, 12.2010, p. 1651-1656.

Research output: Contribution to journalArticle

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