Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task

Norazrina Azmi, Christine Norman, Clare H. Spicer, Geoffrey W. Bennett

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Various lines of evidence suggest a role in cognition for the endogenous neuropeptide, neurotensin, involving an interaction with the central nervous system cholinergic pathways. A preliminary study has shown that central administration of neurotensin enhances spatial and nonspatial working memory in the presence of scopolamine, a muscarinic receptor antagonist which induces memory deficits. Utilizing similar methods, the present study employed a two-trial novel object discrimination task to determine the acute effect of a neurotensin peptide analogue with improved metabolic stability, PD149163, on recognition memory in Lister hooded rats. Consistent with previous findings with neurotensin, animals receiving an intracerebroventricular injection of PD149163 (3 μg) significantly discriminated the novel from familiar object during the choice trial. In addition, a similar dose of PD149163 restored the scopolamine-induced deficit in novelty recognition. The restoration effect on scopolamine-induced amnesia produced by PD149163 was blocked by SR142948A, a nonselective neurotensin receptor antagonist, at a dose of 1 mg/kg (intraperitonial) but not at 0.1 mg/kg. In conclusion, the present results confirm a role for neurotensin in mediating memory processes, possibly via central cholinergic mechanisms.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
JournalBehavioural Pharmacology
Volume17
Issue number4
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Neurotensin
Scopolamine Hydrobromide
Cholinergic Agents
Neurotensin Receptors
Muscarinic Antagonists
Amnesia
Memory Disorders
Muscarinic Receptors
Neuropeptides
Short-Term Memory
Cognition
Central Nervous System
Discrimination (Psychology)
Peptides
Injections

Keywords

  • Cholinergic pathways
  • Memory
  • Neurotensin
  • PD149163
  • Rat
  • SR142948A

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

Cite this

Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. / Azmi, Norazrina; Norman, Christine; Spicer, Clare H.; Bennett, Geoffrey W.

In: Behavioural Pharmacology, Vol. 17, No. 4, 06.2006, p. 357-362.

Research output: Contribution to journalArticle

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