Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome

Mohd Fyzal Bahrudin, Rafiz Abdul Rani, Azmi Mohd. Tamil, Norfilza Mohd Mokhtar, Raja Affendi Raja Ali

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1 Citation (Scopus)

Abstract

Background: This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. Methods: A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified Garrigues questionnaires for pre- and post-consumption were assessed. Results: Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (p < 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (p = 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (p < 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (p = 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (p = 0.308). Constipation-related symptoms were significantly improved for both groups. Conclusions: The addition of polydextrose to sterilized probiotic containing L. helveticus did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing L. helveticus with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.

Original languageEnglish
JournalDigestive Diseases and Sciences
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

polydextrose
Lactobacillus helveticus
Irritable Bowel Syndrome
Probiotics
Constipation
Weights and Measures

Keywords

  • Constipation
  • Irritable bowel syndrome
  • Lactobacillus helveticus
  • Polydextrose
  • Probiotics

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

@article{b265f30ec4cb4878a9dd9fdc1e2f7571,
title = "Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome",
abstract = "Background: This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. Methods: A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified Garrigues questionnaires for pre- and post-consumption were assessed. Results: Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (p < 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (p = 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (p < 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (p = 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (p = 0.308). Constipation-related symptoms were significantly improved for both groups. Conclusions: The addition of polydextrose to sterilized probiotic containing L. helveticus did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing L. helveticus with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.",
keywords = "Constipation, Irritable bowel syndrome, Lactobacillus helveticus, Polydextrose, Probiotics",
author = "Bahrudin, {Mohd Fyzal} and {Abdul Rani}, Rafiz and {Mohd. Tamil}, Azmi and {Mohd Mokhtar}, Norfilza and {Raja Ali}, {Raja Affendi}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s10620-019-05695-3",
language = "English",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",

}

TY - JOUR

T1 - Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome

AU - Bahrudin, Mohd Fyzal

AU - Abdul Rani, Rafiz

AU - Mohd. Tamil, Azmi

AU - Mohd Mokhtar, Norfilza

AU - Raja Ali, Raja Affendi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. Methods: A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified Garrigues questionnaires for pre- and post-consumption were assessed. Results: Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (p < 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (p = 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (p < 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (p = 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (p = 0.308). Constipation-related symptoms were significantly improved for both groups. Conclusions: The addition of polydextrose to sterilized probiotic containing L. helveticus did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing L. helveticus with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.

AB - Background: This study aimed to objectively investigate whether the addition of polydextrose to sterilized probiotic containing Lactobacillus helveticus will confer benefits to constipation-predominant irritable bowel syndrome patients. Methods: A total of 163 patients were randomized into two groups: Group A to consume 350 mL of sterilized probiotic with 5.85 g polydextrose daily for 1 week and Group B without polydextrose. Intestinal transit time, fecal pH, fecal weight, and modified Garrigues questionnaires for pre- and post-consumption were assessed. Results: Median intestinal transit time was significantly reduced from 58 (IQR 43–72) to 45 (IQR 24–59) hours and 48 (IQR 31–72) to 30 (IQR 24–49) hours for Groups A and B, respectively (p < 0.01). Fecal pH for Groups A and B was significantly reduced from 6.57 ± 0.96 to 6.13 ± 0.95 (p = 0.003) and 6.58 ± 1.0 to 5.87 ± 0.83 (p < 0.001), respectively. Fecal weight for Group A was significantly increased from 8 g ± 6.4 g to 9.8 g ± 7.6 g (p = 0.003), but it was reduced for Group B from 13.3 g ± 19.4 g to 11.2 g ± 6.6 g (p = 0.308). Constipation-related symptoms were significantly improved for both groups. Conclusions: The addition of polydextrose to sterilized probiotic containing L. helveticus did not show significant benefits to constipation-predominant irritable bowel syndrome patients. However, daily consumption of sterilized probiotic containing L. helveticus with or without polydextrose for a week alleviated constipation-related symptoms and objectively reduced both fecal pH and intestinal transit time.

KW - Constipation

KW - Irritable bowel syndrome

KW - Lactobacillus helveticus

KW - Polydextrose

KW - Probiotics

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U2 - 10.1007/s10620-019-05695-3

DO - 10.1007/s10620-019-05695-3

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JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

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