Effectiveness of antihypertensive drugs in hypertensive patients with end stage renal failure

Research output: Contribution to journalArticle

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Abstract

Hypertension has been identified as one of the causes for end stage renal failure (ESRF) and is likely to worsen kidney function. This retrospective study was carried out at a tertiary hospital in Malaysia with the objective of determining the effectiveness of combination antihypertensive drugs in hypertensive patients with ESRF admitted between 2006 and 2008. Patients with incomplete data and who were on monotherapy were excluded from this study. Although six different combinations gave significant reductions in systolic blood pressure (SBP) (13.38 ± 9.11 mmHg, p<0.05) and diastolic blood pressure (DBP) (6.03 ± 11.39 mmHg, p<0.05), 69.16% patients did not achieve target blood pressure (BP) (≤ 130/80 mmHg). Combination of beta blocker (BB) with calcium channel blocker (CCB) was the most commonly used. The CCB-diuretic regimen achieved highest percentage of BP control compared to others (40%). Comparison of blood pressure reduction between different combinations of antihypertensive drugs were not significant (p>0.05) except for CCB-diuretics and BB-CCB-alpha blocker. The findings suggested better BP control with CCBdiuretic relative to other combinations used.

Original languageEnglish
Pages (from-to)379-385
Number of pages7
JournalMedical Journal of Malaysia
Volume67
Issue number4
Publication statusPublished - Aug 2012

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Antihypertensive Agents
Chronic Kidney Failure
Blood Pressure
Malaysia
Diuretics
Tertiary Care Centers
Retrospective Studies
Hypertension
Kidney

Keywords

  • Antihypertensive drugs
  • Combination therapy
  • Efficacy
  • End stage renal failure
  • Hypertension

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effectiveness of antihypertensive drugs in hypertensive patients with end stage renal failure. / Endang, Kumolosasi Msi; Ng, Wen Bin; Abdul Aziz, Siti Azdiah.

In: Medical Journal of Malaysia, Vol. 67, No. 4, 08.2012, p. 379-385.

Research output: Contribution to journalArticle

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