Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats

Wan Zurinah Wan Ngah, Zanariah Jarien, Myint Myint San, Alini Marzuki, Gapor Md Top, Nor Aripin Shamaan, Khalid Abdul Kadir

    Research output: Contribution to journalArticle

    72 Citations (Scopus)

    Abstract

    The effects of tocotrienols on hepatocarcinogenesis in rats fed with 2-acetylaminofluorene (AAF) were followed morphologically and histologically for a period of 20 wk. No differences between treated and control rats in the morphology and histology of their livers was observed. Cell damage was extensive in the livers of AAF-treated rats but less extensive in the AAF-tocotrienols-treated rats when compared with normal and tocotrienols-treated rats. 2-Acetylaminofluorene significantly increases the activities of both plasma and liver microsomal γ-glutamyltranspeptidase (GGT) and liver microsomal UDP-glucuronyltransferase (UDP-GT). Tocotrienols administered together with AAF significantly decrease the activities of plasma GGT after 12 and 20 wk (P < 0.01, P < 0.002. respectively) and liver microsomal UDP-GT after 20 wk (P < 0.02) when compared with the controls and with rats treated only with tocotrienols. Liver microsomal GGT also showed a similar pattern to liver microsomal UDP-GT but the decrease was not significant. These results suggest that tocotrienols administered to AAF-treated rats reduce the severity of hepatocarcinogenesis.

    Original languageEnglish
    JournalAmerican Journal of Clinical Nutrition
    Volume53
    Issue numberSUPPL. 4
    Publication statusPublished - Apr 1991

    Fingerprint

    Tocotrienols
    2-Acetylaminofluorene
    tocotrienols
    liver
    Liver
    rats
    Glucuronosyltransferase
    Uridine Diphosphate
    histology
    Histology

    Keywords

    • γ-glutamyltranspeptidase
    • 2-acetylaminofluorene
    • Carcinogenesis
    • Tocotrienols
    • UDP-glucuronyltransferase
    • Vitamin E

    ASJC Scopus subject areas

    • Food Science
    • Medicine (miscellaneous)

    Cite this

    Wan Ngah, W. Z., Jarien, Z., San, M. M., Marzuki, A., Md Top, G., Shamaan, N. A., & Abdul Kadir, K. (1991). Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. American Journal of Clinical Nutrition, 53(SUPPL. 4).

    Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. / Wan Ngah, Wan Zurinah; Jarien, Zanariah; San, Myint Myint; Marzuki, Alini; Md Top, Gapor; Shamaan, Nor Aripin; Abdul Kadir, Khalid.

    In: American Journal of Clinical Nutrition, Vol. 53, No. SUPPL. 4, 04.1991.

    Research output: Contribution to journalArticle

    Wan Ngah, WZ, Jarien, Z, San, MM, Marzuki, A, Md Top, G, Shamaan, NA & Abdul Kadir, K 1991, 'Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats', American Journal of Clinical Nutrition, vol. 53, no. SUPPL. 4.
    Wan Ngah WZ, Jarien Z, San MM, Marzuki A, Md Top G, Shamaan NA et al. Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. American Journal of Clinical Nutrition. 1991 Apr;53(SUPPL. 4).
    Wan Ngah, Wan Zurinah ; Jarien, Zanariah ; San, Myint Myint ; Marzuki, Alini ; Md Top, Gapor ; Shamaan, Nor Aripin ; Abdul Kadir, Khalid. / Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. In: American Journal of Clinical Nutrition. 1991 ; Vol. 53, No. SUPPL. 4.
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