Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene

Nor Aripin Shamaan, Wan Zurinah Wan Ngah, Rusli Ibrahim, Zanariah Jarien, Abdul Gapor Md Top, Khalid Abdul Kadir

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    The effect of tocotrienol on the activities of glutathione S-transferases (GSTs), glutathione reductase (GR) and glutathione peroxidase (GPx) in rats given 2-acetylaminofluorene (AAF) was investigated over a 20 week period. Liver and kidney GST and liver GR activities were significantly increased after AAF administration. Kidney GPx activities were significantly affected; activity assayed with cumene hydroperoxide (cu-OOH) was increased but activity assayed with H2O2 was reduced. Supplementation of the diet with tocotrienol in the AAF-treated rats reduced the increase in enzyme activities. Tocotrienol on its own had no effect on the enzyme activities.

    Original languageEnglish
    Pages (from-to)1517-1519
    Number of pages3
    JournalBiochemical Pharmacology
    Volume45
    Issue number7
    DOIs
    Publication statusPublished - 6 Apr 1993

    Fingerprint

    Tocotrienols
    2-Acetylaminofluorene
    Glutathione
    Rats
    Glutathione Reductase
    Enzyme activity
    Glutathione Peroxidase
    Glutathione Transferase
    Liver
    Enzymes
    Kidney
    Nutrition
    Diet

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene. / Shamaan, Nor Aripin; Wan Ngah, Wan Zurinah; Ibrahim, Rusli; Jarien, Zanariah; Md Top, Abdul Gapor; Kadir, Khalid Abdul.

    In: Biochemical Pharmacology, Vol. 45, No. 7, 06.04.1993, p. 1517-1519.

    Research output: Contribution to journalArticle

    Shamaan, Nor Aripin ; Wan Ngah, Wan Zurinah ; Ibrahim, Rusli ; Jarien, Zanariah ; Md Top, Abdul Gapor ; Kadir, Khalid Abdul. / Effect of tocotrienol on the activities of cytosolic glutathione-dependent enzymes in rats treated with 2-acetylaminofluorene. In: Biochemical Pharmacology. 1993 ; Vol. 45, No. 7. pp. 1517-1519.
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    AU - Ibrahim, Rusli

    AU - Jarien, Zanariah

    AU - Md Top, Abdul Gapor

    AU - Kadir, Khalid Abdul

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