Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats

Farkaad A. Kadir, Faizah Othman, Mahmood Ameen Abdulla, Khin Pa Pa Hlaing @ Farida Hussan, Pouya Hassandarvish

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objectives: This study was conducted to determine the effect of ethanolic extract of the dried stems of Tinospora crispa in a male rat model of hepatic fibrosis caused by the hepatotoxin, thioacetamide. Materials and Methods: The extract was gavaged daily to the rats, at doses of 100 and 200 mg/kg along with thioacetamide at a dose of 200 mg/kg twice weekly. To assess the effectivity of extract, against thioacetamide, the activity of aminotransferases (alanine aminotransferase, aspartate aminotransferase), alkaline phosphatase (AP); and bilirubin were measured, together with morphological and histopathological indices in the liver of healthy and thioacetamide-treated rats. Results: A significant increase in the activity of liver enzymes, bilirubin and G-glutamyl transferase and gross and histopathological changes were determined. Although previous in vitro study established that this extract had strong antioxidant activity, this in vivo study establishes that this extract contains hepatotoxins whose identity may be quite different from those compounds with antioxidant properties. Conclusion: The study confirms that complete reliance on data obtained using in vitro methodologies may lead to erroneous conclusions pertaining to the safety of phytopharmaceuticals.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalIndian Journal of Pharmacology
Volume43
Issue number1
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Tinospora
Thioacetamide
Liver Cirrhosis
Bilirubin
Liver
Antioxidants
Transferases
Aspartate Aminotransferases
Transaminases
Alanine Transaminase
Alkaline Phosphatase
Fibrosis
Safety
Enzymes

Keywords

  • Antioxidant
  • ethanol extract
  • liver cirrhosis
  • Tinospora crispa
  • traditional medicine

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Kadir, F. A., Othman, F., Abdulla, M. A., Pa Pa Hlaing @ Farida Hussan, K., & Hassandarvish, P. (2011). Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. Indian Journal of Pharmacology, 43(1), 64-68. https://doi.org/10.4103/0253-7613.75673

Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. / Kadir, Farkaad A.; Othman, Faizah; Abdulla, Mahmood Ameen; Pa Pa Hlaing @ Farida Hussan, Khin; Hassandarvish, Pouya.

In: Indian Journal of Pharmacology, Vol. 43, No. 1, 02.2011, p. 64-68.

Research output: Contribution to journalArticle

Kadir, FA, Othman, F, Abdulla, MA, Pa Pa Hlaing @ Farida Hussan, K & Hassandarvish, P 2011, 'Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats', Indian Journal of Pharmacology, vol. 43, no. 1, pp. 64-68. https://doi.org/10.4103/0253-7613.75673
Kadir FA, Othman F, Abdulla MA, Pa Pa Hlaing @ Farida Hussan K, Hassandarvish P. Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. Indian Journal of Pharmacology. 2011 Feb;43(1):64-68. https://doi.org/10.4103/0253-7613.75673
Kadir, Farkaad A. ; Othman, Faizah ; Abdulla, Mahmood Ameen ; Pa Pa Hlaing @ Farida Hussan, Khin ; Hassandarvish, Pouya. / Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats. In: Indian Journal of Pharmacology. 2011 ; Vol. 43, No. 1. pp. 64-68.
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