Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults

Goon Jo Aan, A. H. Noor Aini, M. Musalmah, Yasmin Anum Mohd Yusof, W. M. Wan Nazaimoon, W. Z. Wan Ngah

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: The biochemical mechanisms involving oxidative stress to explain the relationship between exercise and healthy aging are still unclear. Methods: Tai Chi participants and matched sedentary volunteers age 45 and above were enrolled. Glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities; levels of DNA damage using the comet assay; and malondialdehyde (MDA) and advanced glycation end products (AGE) were determined at 0, 6, and 12 months. Results: Tai Chi subjects had decreased normal and increased mildly damaged DNA with elevated GPx activity after 6 months (n = 25). Plasma MDA and AGE concentrations decreased significantly after 12 months (n = 15) accompanied by increased SOD activity. This may be attributed to the hormesis effect, whereby mild induction of oxidative stress at the first 6 months of exercise resulted in stimulation of antioxidant defenses. These parameters were unchanged in the sedentary subjects in the first 6 months (n = 27) except for elevated SOD activity. After 12 months, the sedentary subjects (n = 17) had decreased normal DNA and increased severely damaged DNA with unaltered MDA and AGE levels while SOD and GPx activities were significantly elevated. Conclusion: Regular Tai Chi exercise stimulated endogenous antioxidant enzymes and reduced oxidative damage markers.

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalJournal of Physical Activity and Health
Volume6
Issue number1
Publication statusPublished - Jan 2009

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Tai Ji
Advanced Glycosylation End Products
DNA Damage
Superoxide Dismutase
Oxidative Stress
Glutathione Peroxidase
Antioxidants
Malondialdehyde
Exercise
Enzymes
DNA
Hormesis
Comet Assay
Catalase
Volunteers

Keywords

  • Aging
  • Exercise
  • Intervention study
  • Older adults
  • Physical activity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Jo Aan, G., Noor Aini, A. H., Musalmah, M., Mohd Yusof, Y. A., Wan Nazaimoon, W. M., & Wan Ngah, W. Z. (2009). Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. Journal of Physical Activity and Health, 6(1), 43-54.

Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. / Jo Aan, Goon; Noor Aini, A. H.; Musalmah, M.; Mohd Yusof, Yasmin Anum; Wan Nazaimoon, W. M.; Wan Ngah, W. Z.

In: Journal of Physical Activity and Health, Vol. 6, No. 1, 01.2009, p. 43-54.

Research output: Contribution to journalArticle

Jo Aan, G, Noor Aini, AH, Musalmah, M, Mohd Yusof, YA, Wan Nazaimoon, WM & Wan Ngah, WZ 2009, 'Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults', Journal of Physical Activity and Health, vol. 6, no. 1, pp. 43-54.
Jo Aan, Goon ; Noor Aini, A. H. ; Musalmah, M. ; Mohd Yusof, Yasmin Anum ; Wan Nazaimoon, W. M. ; Wan Ngah, W. Z. / Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. In: Journal of Physical Activity and Health. 2009 ; Vol. 6, No. 1. pp. 43-54.
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