Effect of rutacea plant extract (ADD-X) on inflammatory biomarkers, cardiac LDL, troponin T and histological changes in ovariectomized rats fed with heated palm oil

Kumeshini Sukalingam, Kamsiah Jaarin, Qodriyah Mohd Saad, Suhaila Mohamed, Faizah Othman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Palm oil is chief vegetable oil usually consumed worldwide. The consumption of repeatedly heated palm oil produces detrimental effect that attributes to the development of cardiovascular diseases. This study was aimed to determine the effects of ADD-X and repeatedly heated palm oil mixed with 2% cholesterol diet on cardiac, inflammatory biomarkers and histogical changes in ovarectmized rats. Based on the administration of food, animals were divided into 7 groups with 6 rats each. All groups of the animals were ovariectomized except sham after anesthetized. The study was conducted for 6 months. Group I-Sham control fed with Normal rat chow (Sham); Group II-fed with Normal rat chow [Ovx (n)]; Group III-fed with 2% cholesterol chow [Ovx (c)]; Group IV-fed with 2% cholesterol chow mixed with five times heated palm oil (5HPO); Group V-fed with 2% cholesterol chow mixed with five times heated palm oil and ADD-X extract (5HPO-X); Group VI-fed with 2% cholesterol chow mixed with ten times heated palm oil (10HPO); Group VII fed with 2% cholesterol chow mixed with ten times heated palm oil and ADD-X extract (10HPO-X). The rats were sacrificed at the end of the study; blood was collected for cardiac and inflammatory biomarkers. The cardiac tissues of all groups were obtained for biochemical parameters and processed for histopathological examinations. Five times (5HPO) and ten times heated (10HPO) palm oil caused a significant (p

Original languageEnglish
Pages (from-to)223-231
Number of pages9
JournalInternational Journal of Toxicological and Pharmacological Research
Volume8
Issue number4
Publication statusPublished - 1 Aug 2016

Fingerprint

Rutaceae
Troponin T
Plant Extracts
Biomarkers
Cholesterol
Plant Oils
oxidized low density lipoprotein
palm oil
Cardiovascular Diseases
Diet
Food

Keywords

  • ADD-X
  • Cardiac and inflammatory markers
  • Heated palm oil
  • Post menopausal rat models

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of rutacea plant extract (ADD-X) on inflammatory biomarkers, cardiac LDL, troponin T and histological changes in ovariectomized rats fed with heated palm oil. / Sukalingam, Kumeshini; Jaarin, Kamsiah; Mohd Saad, Qodriyah; Mohamed, Suhaila; Othman, Faizah.

In: International Journal of Toxicological and Pharmacological Research, Vol. 8, No. 4, 01.08.2016, p. 223-231.

Research output: Contribution to journalArticle

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