Effect of preoperative oral pregabalin on postoperative pain after mastectomy

Mardhiah Sarah Harnani Mansor, Choy Yin Choy

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Background: This was a randomized, double-blinded clinical trial to study the effects of a single oral dose of pregabalin 150 mg in postoperative pain management after mastectomy. Methods: Design: forty nine patients ASA I or II, aged between 20-60 years, scheduled for mastectomy with or without axillary lymph nodes dissection (ALND) were recruited into this study. They were randomized into two groups, placebo (n = 24) or pregabalin (n = 25) receiving either oral pregabalin 150 mg or placebo when called to operation theatre (OT). The assessment of pain score were performed at recovery, 2, 4, 6 and 24 hours postoperatively at rest and on movement, using the verbal numeral rating score (VNRS). Results: VNRS scores for pain at rest were lower in the pregabalin group at 2 (p = 0.024), 4 (p = 0.006) and 6 (p = 0.003) hours postoperatively, and also at 4 (p = 0.005) and 6 (p = 0.016) hours postoperatively on movement compared to the placebo group. Incidences of dizziness were common, however, side effects such as nausea and vomiting, headache, somnolence and visual disturbance were low and comparable in both groups. Conclusion: a single dose of 150 mg pregabalin given preoperatively compared to placebo significantly reduced postoperative pain scores after mastectomy.

    Original languageEnglish
    Pages (from-to)63-68
    Number of pages6
    JournalMiddle East Journal of Anesthesiology
    Volume23
    Issue number1
    Publication statusPublished - 2015

    Fingerprint

    Mastectomy
    Postoperative Pain
    Placebos
    Dizziness
    Pain Measurement
    Pain Management
    Lymph Node Excision
    Nausea
    Vomiting
    Headache
    Pregabalin
    Clinical Trials
    Pain
    Incidence

    Keywords

    • Mastectomy
    • Opioid
    • Postoperative pain
    • Pregabalin

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine

    Cite this

    Effect of preoperative oral pregabalin on postoperative pain after mastectomy. / Mansor, Mardhiah Sarah Harnani; Choy, Choy Yin.

    In: Middle East Journal of Anesthesiology, Vol. 23, No. 1, 2015, p. 63-68.

    Research output: Contribution to journalArticle

    Mansor, Mardhiah Sarah Harnani ; Choy, Choy Yin. / Effect of preoperative oral pregabalin on postoperative pain after mastectomy. In: Middle East Journal of Anesthesiology. 2015 ; Vol. 23, No. 1. pp. 63-68.
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