Abstract
Background: This was a randomized, double-blinded clinical trial to study the effects of a single oral dose of pregabalin 150 mg in postoperative pain management after mastectomy. Methods: Design: forty nine patients ASA I or II, aged between 20-60 years, scheduled for mastectomy with or without axillary lymph nodes dissection (ALND) were recruited into this study. They were randomized into two groups, placebo (n = 24) or pregabalin (n = 25) receiving either oral pregabalin 150 mg or placebo when called to operation theatre (OT). The assessment of pain score were performed at recovery, 2, 4, 6 and 24 hours postoperatively at rest and on movement, using the verbal numeral rating score (VNRS). Results: VNRS scores for pain at rest were lower in the pregabalin group at 2 (p = 0.024), 4 (p = 0.006) and 6 (p = 0.003) hours postoperatively, and also at 4 (p = 0.005) and 6 (p = 0.016) hours postoperatively on movement compared to the placebo group. Incidences of dizziness were common, however, side effects such as nausea and vomiting, headache, somnolence and visual disturbance were low and comparable in both groups. Conclusion: a single dose of 150 mg pregabalin given preoperatively compared to placebo significantly reduced postoperative pain scores after mastectomy.
| Original language | English |
|---|---|
| Pages (from-to) | 63-68 |
| Number of pages | 6 |
| Journal | Middle East Journal of Anesthesiology |
| Volume | 23 |
| Issue number | 1 |
| Publication status | Published - 2015 |
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Keywords
- Mastectomy
- Opioid
- Postoperative pain
- Pregabalin
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Effect of preoperative oral pregabalin on postoperative pain after mastectomy. / Mansor, Mardhiah Sarah Harnani; Choy, Choy Yin.
In: Middle East Journal of Anesthesiology, Vol. 23, No. 1, 2015, p. 63-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of preoperative oral pregabalin on postoperative pain after mastectomy
AU - Mansor, Mardhiah Sarah Harnani
AU - Choy, Choy Yin
PY - 2015
Y1 - 2015
N2 - Background: This was a randomized, double-blinded clinical trial to study the effects of a single oral dose of pregabalin 150 mg in postoperative pain management after mastectomy. Methods: Design: forty nine patients ASA I or II, aged between 20-60 years, scheduled for mastectomy with or without axillary lymph nodes dissection (ALND) were recruited into this study. They were randomized into two groups, placebo (n = 24) or pregabalin (n = 25) receiving either oral pregabalin 150 mg or placebo when called to operation theatre (OT). The assessment of pain score were performed at recovery, 2, 4, 6 and 24 hours postoperatively at rest and on movement, using the verbal numeral rating score (VNRS). Results: VNRS scores for pain at rest were lower in the pregabalin group at 2 (p = 0.024), 4 (p = 0.006) and 6 (p = 0.003) hours postoperatively, and also at 4 (p = 0.005) and 6 (p = 0.016) hours postoperatively on movement compared to the placebo group. Incidences of dizziness were common, however, side effects such as nausea and vomiting, headache, somnolence and visual disturbance were low and comparable in both groups. Conclusion: a single dose of 150 mg pregabalin given preoperatively compared to placebo significantly reduced postoperative pain scores after mastectomy.
AB - Background: This was a randomized, double-blinded clinical trial to study the effects of a single oral dose of pregabalin 150 mg in postoperative pain management after mastectomy. Methods: Design: forty nine patients ASA I or II, aged between 20-60 years, scheduled for mastectomy with or without axillary lymph nodes dissection (ALND) were recruited into this study. They were randomized into two groups, placebo (n = 24) or pregabalin (n = 25) receiving either oral pregabalin 150 mg or placebo when called to operation theatre (OT). The assessment of pain score were performed at recovery, 2, 4, 6 and 24 hours postoperatively at rest and on movement, using the verbal numeral rating score (VNRS). Results: VNRS scores for pain at rest were lower in the pregabalin group at 2 (p = 0.024), 4 (p = 0.006) and 6 (p = 0.003) hours postoperatively, and also at 4 (p = 0.005) and 6 (p = 0.016) hours postoperatively on movement compared to the placebo group. Incidences of dizziness were common, however, side effects such as nausea and vomiting, headache, somnolence and visual disturbance were low and comparable in both groups. Conclusion: a single dose of 150 mg pregabalin given preoperatively compared to placebo significantly reduced postoperative pain scores after mastectomy.
KW - Mastectomy
KW - Opioid
KW - Postoperative pain
KW - Pregabalin
UR - http://www.scopus.com/inward/record.url?scp=84930837259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930837259&partnerID=8YFLogxK
M3 - Article
C2 - 26121897
AN - SCOPUS:84930837259
VL - 23
SP - 63
EP - 68
JO - Middle East Journal of Anesthesiology
JF - Middle East Journal of Anesthesiology
SN - 0544-0440
IS - 1
ER -