Effect of polyethylene glycol-2000 on amino acid surfactant-based vesicles

Nasima Akter, Shahidan Radiman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polyethylene glycol (PEG)-modified amino acid surfactant-based vesicles were prepared to improve the stability and cellular delivery of drugs. The vesicles comprised PEG-2000, sodium N-lauroylsarcosinate hydrate (SNLS), 1-decanol, and deionized water. The complex showed vesicular structures that were almost the same as the original vesicles, and their size distribution was (100-150 nm). Transmission electron microscopy (TEM) results revealed that no fusion occurred at 1.25 wt.% PEG concentration. The steric hindrance present among the vesicles prevented aggregation of the particles. No visual phase separation was observed for 6 months at room temperature 28°C. At higher molar concentration of PEG, fusion and wrinkling occurred owing to the association of PEG chains. The decreasing bending curvature led to the formation of fused vesicles with multilayer structure, as revealed by TEM and differential scanning calorimetry (DSC).

Original languageEnglish
Pages (from-to)1619-1625
Number of pages7
JournalColloid and Polymer Science
Volume292
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Surface-Active Agents
Polyethylene glycols
amino acids
Amino acids
glycols
polyethylenes
Surface active agents
surfactants
Amino Acids
Fusion reactions
Transmission electron microscopy
fusion
Deionized water
wrinkling
Hydrates
transmission electron microscopy
Phase separation
Differential scanning calorimetry
Multilayers
Agglomeration

Keywords

  • Adsorption
  • Amino acid
  • Biosurfactant
  • Hydrogen bonding
  • Melting temperature
  • Membrane
  • Polyethylene glycol-2000
  • Vesicles

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Polymers and Plastics
  • Materials Chemistry
  • Colloid and Surface Chemistry

Cite this

Effect of polyethylene glycol-2000 on amino acid surfactant-based vesicles. / Akter, Nasima; Radiman, Shahidan.

In: Colloid and Polymer Science, Vol. 292, No. 7, 2014, p. 1619-1625.

Research output: Contribution to journalArticle

Akter, Nasima ; Radiman, Shahidan. / Effect of polyethylene glycol-2000 on amino acid surfactant-based vesicles. In: Colloid and Polymer Science. 2014 ; Vol. 292, No. 7. pp. 1619-1625.
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