Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats

Kamsiah Jaarin, M. Renuvathani, M. I. Nafeeza, M. T. Gapor

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The effect of palm vitamin E on the healing of ethanol-induced gastric lesions and various biochemical parameters were investigated. The study was divided into two phases. In the first phase of the study, 42 rats of Sprague Dawley species (200-250 gm weight) were randomly divided into two groups fed with a normal diet (control) or palm vitamin E enriched diet (150 mg/kg) for 3 weeks. The rats were killed after 3 weeks of feeding. Gastric tissue contents of malondialdehyde (MDA), prostaglandin E2 and acid were measured. In the second phase of the study 42 rats were divided into two groups. Group 1 was fed normal rat pellets (control) and group 2 was fed palm vitamin E enriched pellets (150 mg/kg food) for 3 weeks. After 3 weeks of feeding gastric mucosal injury was induced by an orogastric tube administration of 0.5 ml 100% ethanol. The rats were killed at 1 hour, 4 hours and 1 week after ethanol exposure for semiquantitative determination of ulcer index and gastric acid concentration. Gastric tissue MDA and muscus were measured only at 1 week after ethanol exposure. In the first phase of the study we found that palm vitamin E only caused a significant reduction in gastric MDA. However, it showed no significant effects on prostaglandin E2 and gastric acid concentration. In the second phase of the study, the mean ulcer index of palm vitamin E supplemented group killed after 1 week of ethanol exposure was significantly lower compared to the respective control. However, there was no significant difference in ulcer index in rats killed at 1 hour and 24 hours after ethanol exposure. The gastric acid concentration was significantly higher in the group treated with palm vitamin E killed 1 week after ethanol exposure compared to control. The gastric tissue MDA was significantly lower in the palm vitamin E supplemented group compared to control. There was no significant difference in gastric mucus content of the both groups. The ulcer healing which occurred in the presence of a high gastric acid suggests that the effect of palm vitamin E on the healing of gastric lesions was not mediated via a reduction in gastric acid nor was it mediated through increasing prostaglandin E2 or mucus production. The most probable mechanism is via reducing lipid peroxidation as reflected by a significant decreased in gastric tissue MDA content.

Original languageEnglish
JournalInternational Journal of Food Sciences and Nutrition
Volume51
Issue numberSUPPL.
Publication statusPublished - 2000

Fingerprint

Vitamin E
vitamin E
Stomach
stomach
Ethanol
ethanol
gastric acid
Gastric Acid
Malondialdehyde
rats
Wounds and Injuries
malondialdehyde
Ulcer
Dinoprostone
Gastrointestinal Contents
prostaglandins
Mucus
mucus
lesions (animal)
pellets

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats. / Jaarin, Kamsiah; Renuvathani, M.; Nafeeza, M. I.; Gapor, M. T.

In: International Journal of Food Sciences and Nutrition, Vol. 51, No. SUPPL., 2000.

Research output: Contribution to journalArticle

Jaarin, Kamsiah ; Renuvathani, M. ; Nafeeza, M. I. ; Gapor, M. T. / Effect of palm vitamin E on the healing of ethanol-induced gastric injury in rats. In: International Journal of Food Sciences and Nutrition. 2000 ; Vol. 51, No. SUPPL.
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