Effect of Nigella sativa supplementation on human lipids

Systematic review

Redhwan Ahmed Al-Naggar, Muhamed T. Osman, Isa Naina Mohamed, Khairun Nain Bin Nor Aripin, Mahfoudh A.M. Abdulghani

Research output: Contribution to journalReview article

Abstract

Nigella sativa (NS) is widely used in traditional medicine and several studies have been conducted to reveal NS effects on different medical disorders including hyperlipidemia. Since hyperlipidemia is a common risk factor for the development of cardiovascular illness. We evaluated the effects of NS supplementation on lipid profile in clinical trial performed among humans. A search on published studies was done by using databases including Scopus, PubMed, Google Scholar, Thomas Reuters Web of Science, and CINAHIL. Terms searched included "Nigella sativa, Black seed, Black cumin, Triglycerides, Cholesterol, Lipoproteins". Initially 432 articles were extracted. However, four hundred eighteen papers were unrelated, reviews, animal studies, combined and duplicated studies were excluded, and finally only fourteen articles were eligible for this review. After analysing 14 articles including 738 participants from different countries and nations. Results of these clinical trials revealed that Nigella sativa is effective to change the lipid profile significantly in different conditions. This systematic review revealed that Nigella sativa supplementation might be effective in hyperlipidemic control in humans and seems potential target of future drug for hyperlipidemic conditions.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalJournal of Applied Pharmaceutical Science
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Apr 2017

Fingerprint

Nigella sativa
Lipids
Hyperlipidemias
Clinical Trials
Traditional Medicine
PubMed
Seeds
Triglycerides
Databases

Keywords

  • Black seeds
  • Human lipids
  • Hyperlipidemia
  • Lipid profile
  • Nigella sativa

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Effect of Nigella sativa supplementation on human lipids : Systematic review. / Al-Naggar, Redhwan Ahmed; Osman, Muhamed T.; Naina Mohamed, Isa; Aripin, Khairun Nain Bin Nor; Abdulghani, Mahfoudh A.M.

In: Journal of Applied Pharmaceutical Science, Vol. 7, No. 4, 01.04.2017, p. 213-219.

Research output: Contribution to journalReview article

Al-Naggar, Redhwan Ahmed ; Osman, Muhamed T. ; Naina Mohamed, Isa ; Aripin, Khairun Nain Bin Nor ; Abdulghani, Mahfoudh A.M. / Effect of Nigella sativa supplementation on human lipids : Systematic review. In: Journal of Applied Pharmaceutical Science. 2017 ; Vol. 7, No. 4. pp. 213-219.
@article{fd7b03478c1241e29c00e303e2a70ceb,
title = "Effect of Nigella sativa supplementation on human lipids: Systematic review",
abstract = "Nigella sativa (NS) is widely used in traditional medicine and several studies have been conducted to reveal NS effects on different medical disorders including hyperlipidemia. Since hyperlipidemia is a common risk factor for the development of cardiovascular illness. We evaluated the effects of NS supplementation on lipid profile in clinical trial performed among humans. A search on published studies was done by using databases including Scopus, PubMed, Google Scholar, Thomas Reuters Web of Science, and CINAHIL. Terms searched included {"}Nigella sativa, Black seed, Black cumin, Triglycerides, Cholesterol, Lipoproteins{"}. Initially 432 articles were extracted. However, four hundred eighteen papers were unrelated, reviews, animal studies, combined and duplicated studies were excluded, and finally only fourteen articles were eligible for this review. After analysing 14 articles including 738 participants from different countries and nations. Results of these clinical trials revealed that Nigella sativa is effective to change the lipid profile significantly in different conditions. This systematic review revealed that Nigella sativa supplementation might be effective in hyperlipidemic control in humans and seems potential target of future drug for hyperlipidemic conditions.",
keywords = "Black seeds, Human lipids, Hyperlipidemia, Lipid profile, Nigella sativa",
author = "Al-Naggar, {Redhwan Ahmed} and Osman, {Muhamed T.} and {Naina Mohamed}, Isa and Aripin, {Khairun Nain Bin Nor} and Abdulghani, {Mahfoudh A.M.}",
year = "2017",
month = "4",
day = "1",
doi = "10.7324/JAPS.2017.70432",
language = "English",
volume = "7",
pages = "213--219",
journal = "Journal of Applied Pharmaceutical Science",
issn = "2231-3354",
publisher = "MediPoeia",
number = "4",

}

TY - JOUR

T1 - Effect of Nigella sativa supplementation on human lipids

T2 - Systematic review

AU - Al-Naggar, Redhwan Ahmed

AU - Osman, Muhamed T.

AU - Naina Mohamed, Isa

AU - Aripin, Khairun Nain Bin Nor

AU - Abdulghani, Mahfoudh A.M.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Nigella sativa (NS) is widely used in traditional medicine and several studies have been conducted to reveal NS effects on different medical disorders including hyperlipidemia. Since hyperlipidemia is a common risk factor for the development of cardiovascular illness. We evaluated the effects of NS supplementation on lipid profile in clinical trial performed among humans. A search on published studies was done by using databases including Scopus, PubMed, Google Scholar, Thomas Reuters Web of Science, and CINAHIL. Terms searched included "Nigella sativa, Black seed, Black cumin, Triglycerides, Cholesterol, Lipoproteins". Initially 432 articles were extracted. However, four hundred eighteen papers were unrelated, reviews, animal studies, combined and duplicated studies were excluded, and finally only fourteen articles were eligible for this review. After analysing 14 articles including 738 participants from different countries and nations. Results of these clinical trials revealed that Nigella sativa is effective to change the lipid profile significantly in different conditions. This systematic review revealed that Nigella sativa supplementation might be effective in hyperlipidemic control in humans and seems potential target of future drug for hyperlipidemic conditions.

AB - Nigella sativa (NS) is widely used in traditional medicine and several studies have been conducted to reveal NS effects on different medical disorders including hyperlipidemia. Since hyperlipidemia is a common risk factor for the development of cardiovascular illness. We evaluated the effects of NS supplementation on lipid profile in clinical trial performed among humans. A search on published studies was done by using databases including Scopus, PubMed, Google Scholar, Thomas Reuters Web of Science, and CINAHIL. Terms searched included "Nigella sativa, Black seed, Black cumin, Triglycerides, Cholesterol, Lipoproteins". Initially 432 articles were extracted. However, four hundred eighteen papers were unrelated, reviews, animal studies, combined and duplicated studies were excluded, and finally only fourteen articles were eligible for this review. After analysing 14 articles including 738 participants from different countries and nations. Results of these clinical trials revealed that Nigella sativa is effective to change the lipid profile significantly in different conditions. This systematic review revealed that Nigella sativa supplementation might be effective in hyperlipidemic control in humans and seems potential target of future drug for hyperlipidemic conditions.

KW - Black seeds

KW - Human lipids

KW - Hyperlipidemia

KW - Lipid profile

KW - Nigella sativa

UR - http://www.scopus.com/inward/record.url?scp=85018958041&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018958041&partnerID=8YFLogxK

U2 - 10.7324/JAPS.2017.70432

DO - 10.7324/JAPS.2017.70432

M3 - Review article

VL - 7

SP - 213

EP - 219

JO - Journal of Applied Pharmaceutical Science

JF - Journal of Applied Pharmaceutical Science

SN - 2231-3354

IS - 4

ER -