Effect of myocardial infarction on spleen and kidney of isoprenaline-induced myocardial injury rat model

Shafreena Shaukat Ali, Nur Hafiqah Rozalei, Siti Fatimah Azaharah Mohamed, Yap Wei Boon, Satirah Zainalabidin

Research output: Contribution to journalArticle

Abstract

Myocardial infarction (MI)-associated inflammation is crucial for post-infarct healing. However, unregulated inflammation may lead to unnecessary systemic inflammation, and affect other organs. This study investigated the effects of MI on spleen and kidneys over early time-points (2 and 7 days) in isoprenaline-induced MI rat model. MI was evident by elevated levels of cardiac injury marker, troponin T, and lactate dehydrogenase (LDH). MI rats showed significant upregulation of myeloperoxidase (MPO) activity at day-2 post infarct while kidney MPO activity remained unaffected. Kidney function test revealed only slightly increased plasma urea at day-2 post MI with no changes in plasma creatine at both time-points. Histological observation on the spleen showed disorganization of spleen structure at day-2 post MI while the kidney structures were preserved at both time-points. In conclusion, although MI-associated damages in the spleen were seen at day-2 post infarct, it had no impact on the kidney structures at both time-points.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJurnal Teknologi
Volume81
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

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Rats
Plasmas
Urea
Oxidoreductases

Keywords

  • Inflammation
  • Isoprenaline
  • Kidney
  • Myocardial infarction
  • Spleen

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Effect of myocardial infarction on spleen and kidney of isoprenaline-induced myocardial injury rat model. / Ali, Shafreena Shaukat; Rozalei, Nur Hafiqah; Mohamed, Siti Fatimah Azaharah; Boon, Yap Wei; Zainalabidin, Satirah.

In: Jurnal Teknologi, Vol. 81, No. 2, 01.03.2019, p. 47-52.

Research output: Contribution to journalArticle

Ali, Shafreena Shaukat ; Rozalei, Nur Hafiqah ; Mohamed, Siti Fatimah Azaharah ; Boon, Yap Wei ; Zainalabidin, Satirah. / Effect of myocardial infarction on spleen and kidney of isoprenaline-induced myocardial injury rat model. In: Jurnal Teknologi. 2019 ; Vol. 81, No. 2. pp. 47-52.
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