Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics: A randomized controlled trial

Somayyeh Firouzi, Barakatun Nisak Mohd-Yusof, Hazreen Abd Majid, Amin Ismail, Nor Azmi Kamaruddin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The beneficial effect of probiotics on renal profile and liver function has been reported among patients with chronic kidney disease and fatty liver respectively. However, its effect on renal profile and liver function among type 2 diabetic individuals has not been fully understood. To investigate the effect of microbial cell preparation on renal profile and liver function tests among type 2 diabetic individuals. Methods: A randomized, double-blind, parallel-group, controlled clinical trial was conducted on a total of 136 type 2 diabetics age 30-70 years old in a teaching hospital in Kuala Lumpur, Malaysia. Subjects were randomly assigned to receive microbial cell preparation (N = 68) or a placebo (N = 68) for 12 weeks. The outcomes measured at baseline, week 6, and week 12 and included changes in renal profile (Sodium, Potassium, Urea, Creatinine, Glomerular Filtration Rate), and liver function tests (Albumin, Total Protein, Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase). Intention to treat (ITT) analysis was performed on all the recruited subjects, while per protocol (PP) analysis was conducted on those who completed the trial with good compliance. Result: The urea levels significantly declined in the probiotic group. Serum urea levels reduced from 4.26 mmol/L to 4.04 mmol/L in Probiotic Group while it increased in Placebo Group from 4.03 mmol/L to 4.24 mmol/L. These changes were significant between groups in ITT analysis (p = 0.018). Other parameters did not change significantly between groups. Conclusion: 12 weeks supplementation with daily dosage of 6 × 1010 Colony Forming Units of multi-strain microbial cell preparation significantly improved urea levels. Trial registration: (Clinical trials: NCT01752803 ).

Original languageEnglish
Article number433
JournalBMC Complementary and Alternative Medicine
Volume15
Issue number1
DOIs
Publication statusPublished - 12 Dec 2015

Fingerprint

Urea
Probiotics
Randomized Controlled Trials
Kidney
Intention to Treat Analysis
Liver
Liver Function Tests
Placebos
Phosphoprotein Phosphatases
Malaysia
Controlled Clinical Trials
Fatty Liver
Aspartate Aminotransferases
Alanine Transaminase
Glomerular Filtration Rate
Chronic Renal Insufficiency
Teaching Hospitals
Alkaline Phosphatase
Albumins
Creatinine

Keywords

  • Bifidobacterium
  • Lactobacillus
  • Liver function tests
  • Microbial cell preparation
  • Probiotics
  • Renal profile
  • Type 2 diabetes
  • Urea

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Effect of microbial cell preparation on renal profile and liver function among type 2 diabetics : A randomized controlled trial. / Firouzi, Somayyeh; Mohd-Yusof, Barakatun Nisak; Majid, Hazreen Abd; Ismail, Amin; Kamaruddin, Nor Azmi.

In: BMC Complementary and Alternative Medicine, Vol. 15, No. 1, 433, 12.12.2015.

Research output: Contribution to journalArticle

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