Kesan penambahan limonena terhadap mikroemulsi asid oleik/cremophor rh 40/transcutol/air

Translated title of the contribution: Effect of limonene on the oleic acid/cremophor rh 40/transcutol/water microemulsion

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The pseudo-ternary phase diagram of oleic acid/cremophor rh 40/transcutol/water was prepared along the water dilution line at different ratio of surfactant to cosurfactant (Km). The optimum ratio of surfactant to surfactant was Km=2:1. The effect of addition limonene as a mixed oils phase on the system were done with the ratio of oleic acid to limonene at 1:1, 1:2 and 1:3. Addition of limonene is able to form stable microemulsions up to 70-80 wt. % water content for all ratios of oleic acid to limonene. The ratio of limonene:oleic acid (1:1) resulted on the largest microemulsion region was obtained at the ratio of oil:surfactant/cosurfactant (Oil:S/CoS=1:9). The isotropic properties of microemulsion phases were confirmed by polarized light microscopy. Both systems were prepared at Km=2:1 and 1:9 (oil:S/CoS) as well as 1:1 (limonene:oleic acid). The stability and particle size study was performed for both systems and its show that the addition of limonene does not change the properties and microstructure of the system. Electrical conductivity and viscosity study of the systems reveals that transformation from water-in-oil microemulsion (10% and 20 wt. % water) and bicontinuous microemulsion (30% to 50 wt. % water). All microemulsions prepared may have potentials as a drug delivery system and show high stability for over 6 months at 4, 25 and 37°C.

Original languageIndonesian
Pages (from-to)1797-1805
Number of pages9
JournalSains Malaysiana
Volume46
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

Fingerprint

Microemulsions
Oleic Acid
Oils
Water
Surface-Active Agents
Light polarization
limonene
carbitol
cremophor
Water content
Dilution
Phase diagrams
Optical microscopy
Particle size
Viscosity
Microstructure

Keywords

  • Drug delivery
  • Limonene
  • Microemulsion
  • Microemulsion phase
  • Phase diagram

ASJC Scopus subject areas

  • General

Cite this

Kesan penambahan limonena terhadap mikroemulsi asid oleik/cremophor rh 40/transcutol/air. / Zainuddin, N.; Ahmad, Ishak; Abdul Rahman, Irman; Ramli, Suria.

In: Sains Malaysiana, Vol. 46, No. 10, 01.10.2017, p. 1797-1805.

Research output: Contribution to journalArticle

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AU - Ramli, Suria

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