Effect of interaction between polymorphisms in insulin receptor substrate genes in type 2 diabetes mellitus patients with severe/acute hyperglycemia

Hasniza Zaman Huri, Mohd Makmor Bakry, Rosnani Hashim, Norlaila Mustafa, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate whether there are interactions between insulin receptor substrate 1 (IRS1) and insulin receptor substrate 2 (IRS2) that are associated with increased insulin resistance during such episodes. Methods: Testing Haplotype EffectS in Association Studies (THESIAS) software was used to investigate allelic and haplotype interactions between the polymorphisms in 156 T2DM patients with severe or acute hyperglycemia. Results: Binary analysis showed there were significant differences in the haplotype frequencies for the IRS1 and IRS2 polymorphisms based on the insulin resistance status. Nevertheless, estimation of haplotype effects by equality analysis showed no significant interactions (likelihood ratio tests: all p > 0.05) in increased insulin resistance in T2DM patients with severe/acute hyperglycemia. Conclusion: There are no interactions between IRS1 rs1801278 (p.Gly972Arg) and IRS2 rs1805097 (p.Gly1057Asp) polymorphisms that would affect insulin resistance in T2DM patients with severe/acute hyperglycemia.

Original languageEnglish
Pages (from-to)889-894
Number of pages6
JournalTropical Journal of Pharmaceutical Research
Volume13
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Insulin Receptor Substrate Proteins
Insulin Receptor
Hyperglycemia
Type 2 Diabetes Mellitus
Haplotypes
Insulin Resistance
Genes
Software

Keywords

  • Diabetes mellitus
  • Genetic polymorphism
  • Haplotype
  • Hyperglycemia
  • Insulin receptor substrate
  • Insulin resistance
  • Proteins

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Effect of interaction between polymorphisms in insulin receptor substrate genes in type 2 diabetes mellitus patients with severe/acute hyperglycemia. / Huri, Hasniza Zaman; Makmor Bakry, Mohd; Hashim, Rosnani; Mustafa, Norlaila; Wan Ngah, Wan Zurinah.

In: Tropical Journal of Pharmaceutical Research, Vol. 13, No. 6, 2014, p. 889-894.

Research output: Contribution to journalArticle

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AU - Hashim, Rosnani

AU - Mustafa, Norlaila

AU - Wan Ngah, Wan Zurinah

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AB - Purpose: To investigate whether there are interactions between insulin receptor substrate 1 (IRS1) and insulin receptor substrate 2 (IRS2) that are associated with increased insulin resistance during such episodes. Methods: Testing Haplotype EffectS in Association Studies (THESIAS) software was used to investigate allelic and haplotype interactions between the polymorphisms in 156 T2DM patients with severe or acute hyperglycemia. Results: Binary analysis showed there were significant differences in the haplotype frequencies for the IRS1 and IRS2 polymorphisms based on the insulin resistance status. Nevertheless, estimation of haplotype effects by equality analysis showed no significant interactions (likelihood ratio tests: all p > 0.05) in increased insulin resistance in T2DM patients with severe/acute hyperglycemia. Conclusion: There are no interactions between IRS1 rs1801278 (p.Gly972Arg) and IRS2 rs1805097 (p.Gly1057Asp) polymorphisms that would affect insulin resistance in T2DM patients with severe/acute hyperglycemia.

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