Effect of increasing heart rate on finger photoplethysmography fitness index (PPGF) in subjects with implanted cardiac pacemakers

Amilia Aminuddin, Isabella Tan, Mark Butlin, Alberto P. Avolio, Hosen Kiat, Edward Barin, Nor Anita Megat Mohd Nordin, Kalaivani Chell

Research output: Contribution to journalArticle

Abstract

Finger photoplethysmography (PPG) is a noninvasive method that measures blood volume changes in the finger. The PPG fitness index (PPGF) has been proposed as an index of vascular risk and vascular aging. The objectives of the study were to determine the effects of heart rate (HR) on the PPGF and to determine whether PPGF is influenced by blood pressure (BP) changes. Twenty subjects (78±8 years, 3 female) with permanent cardiac pacemakers or cardioverter defibrillators were prospectively recruited. HR was changed by pacing, in a random order from 60 to 100 bpm and in 10 bpm increments. At each paced HR, the PPGF was derived from a finger photoplethysmogram. Cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) were derived from the finger arterial pressure waveform. Brachial blood pressure (BP) was measured by the oscillometric method. This study found that as HR was increased from 60 to 100 bpm, brachial diastolic BP, brachial mean BP and CO were significantly increased (p<0.01), whilst the PPGF and SV were significantly decreased (p<0.001). The effects of HR on the PPGF were influenced by BP, with a decreasing HR effect on the PPGF that resulted from a higher BP. In conclusion, HR was a significant confounder for PPGF and it must be taken into account in analyses of PPGF, when there are large changes or differences in the HR. The magnitude of this effect was BP dependent.

Original languageEnglish
Article numbere0207301
JournalPLoS One
Volume13
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Photoplethysmography
Pacemakers
Fingers
heart rate
Blood pressure
Heart Rate
blood pressure
Blood Pressure
cardiac output
stroke
blood vessels
Arm
Cardiac Output
Stroke Volume
Blood Vessels
blood volume
diastolic blood pressure
Defibrillators
hypertension
Blood Volume

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Effect of increasing heart rate on finger photoplethysmography fitness index (PPGF) in subjects with implanted cardiac pacemakers. / Aminuddin, Amilia; Tan, Isabella; Butlin, Mark; Avolio, Alberto P.; Kiat, Hosen; Barin, Edward; Nordin, Nor Anita Megat Mohd; Chell, Kalaivani.

In: PLoS One, Vol. 13, No. 11, e0207301, 01.11.2018.

Research output: Contribution to journalArticle

Aminuddin, Amilia ; Tan, Isabella ; Butlin, Mark ; Avolio, Alberto P. ; Kiat, Hosen ; Barin, Edward ; Nordin, Nor Anita Megat Mohd ; Chell, Kalaivani. / Effect of increasing heart rate on finger photoplethysmography fitness index (PPGF) in subjects with implanted cardiac pacemakers. In: PLoS One. 2018 ; Vol. 13, No. 11.
@article{f3eb183c2ab34bf091fe5a09ebc20a57,
title = "Effect of increasing heart rate on finger photoplethysmography fitness index (PPGF) in subjects with implanted cardiac pacemakers",
abstract = "Finger photoplethysmography (PPG) is a noninvasive method that measures blood volume changes in the finger. The PPG fitness index (PPGF) has been proposed as an index of vascular risk and vascular aging. The objectives of the study were to determine the effects of heart rate (HR) on the PPGF and to determine whether PPGF is influenced by blood pressure (BP) changes. Twenty subjects (78±8 years, 3 female) with permanent cardiac pacemakers or cardioverter defibrillators were prospectively recruited. HR was changed by pacing, in a random order from 60 to 100 bpm and in 10 bpm increments. At each paced HR, the PPGF was derived from a finger photoplethysmogram. Cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) were derived from the finger arterial pressure waveform. Brachial blood pressure (BP) was measured by the oscillometric method. This study found that as HR was increased from 60 to 100 bpm, brachial diastolic BP, brachial mean BP and CO were significantly increased (p<0.01), whilst the PPGF and SV were significantly decreased (p<0.001). The effects of HR on the PPGF were influenced by BP, with a decreasing HR effect on the PPGF that resulted from a higher BP. In conclusion, HR was a significant confounder for PPGF and it must be taken into account in analyses of PPGF, when there are large changes or differences in the HR. The magnitude of this effect was BP dependent.",
author = "Amilia Aminuddin and Isabella Tan and Mark Butlin and Avolio, {Alberto P.} and Hosen Kiat and Edward Barin and Nordin, {Nor Anita Megat Mohd} and Kalaivani Chell",
year = "2018",
month = "11",
day = "1",
doi = "10.1371/journal.pone.0207301",
language = "English",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

TY - JOUR

T1 - Effect of increasing heart rate on finger photoplethysmography fitness index (PPGF) in subjects with implanted cardiac pacemakers

AU - Aminuddin, Amilia

AU - Tan, Isabella

AU - Butlin, Mark

AU - Avolio, Alberto P.

AU - Kiat, Hosen

AU - Barin, Edward

AU - Nordin, Nor Anita Megat Mohd

AU - Chell, Kalaivani

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Finger photoplethysmography (PPG) is a noninvasive method that measures blood volume changes in the finger. The PPG fitness index (PPGF) has been proposed as an index of vascular risk and vascular aging. The objectives of the study were to determine the effects of heart rate (HR) on the PPGF and to determine whether PPGF is influenced by blood pressure (BP) changes. Twenty subjects (78±8 years, 3 female) with permanent cardiac pacemakers or cardioverter defibrillators were prospectively recruited. HR was changed by pacing, in a random order from 60 to 100 bpm and in 10 bpm increments. At each paced HR, the PPGF was derived from a finger photoplethysmogram. Cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) were derived from the finger arterial pressure waveform. Brachial blood pressure (BP) was measured by the oscillometric method. This study found that as HR was increased from 60 to 100 bpm, brachial diastolic BP, brachial mean BP and CO were significantly increased (p<0.01), whilst the PPGF and SV were significantly decreased (p<0.001). The effects of HR on the PPGF were influenced by BP, with a decreasing HR effect on the PPGF that resulted from a higher BP. In conclusion, HR was a significant confounder for PPGF and it must be taken into account in analyses of PPGF, when there are large changes or differences in the HR. The magnitude of this effect was BP dependent.

AB - Finger photoplethysmography (PPG) is a noninvasive method that measures blood volume changes in the finger. The PPG fitness index (PPGF) has been proposed as an index of vascular risk and vascular aging. The objectives of the study were to determine the effects of heart rate (HR) on the PPGF and to determine whether PPGF is influenced by blood pressure (BP) changes. Twenty subjects (78±8 years, 3 female) with permanent cardiac pacemakers or cardioverter defibrillators were prospectively recruited. HR was changed by pacing, in a random order from 60 to 100 bpm and in 10 bpm increments. At each paced HR, the PPGF was derived from a finger photoplethysmogram. Cardiac output (CO), stroke volume (SV) and total peripheral resistance (TPR) were derived from the finger arterial pressure waveform. Brachial blood pressure (BP) was measured by the oscillometric method. This study found that as HR was increased from 60 to 100 bpm, brachial diastolic BP, brachial mean BP and CO were significantly increased (p<0.01), whilst the PPGF and SV were significantly decreased (p<0.001). The effects of HR on the PPGF were influenced by BP, with a decreasing HR effect on the PPGF that resulted from a higher BP. In conclusion, HR was a significant confounder for PPGF and it must be taken into account in analyses of PPGF, when there are large changes or differences in the HR. The magnitude of this effect was BP dependent.

UR - http://www.scopus.com/inward/record.url?scp=85057561317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057561317&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0207301

DO - 10.1371/journal.pone.0207301

M3 - Article

C2 - 30485318

AN - SCOPUS:85057561317

VL - 13

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 11

M1 - e0207301

ER -