Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects

Osman Mesaik Mohammed Ahmed Hassan, Asif Ahmed, Ahmed Shukralla Khalid, Saleem Jan, Afaq Ahmed Siddiqui, Shahida Perveen, Muhammad Kamran Azim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The Grewia asiatica (commonly known as Phalsa or Fasla) is a shrub or small tree found in southern Asia. It produces purple to black color fruit when ripe. In folk medicine the edible Grewia asiatica fruit is used in a number of pathological conditions. The current study described the effects of Grewia asiatica fruit on glycemic index (GI) and phagocytosis in healthy non-diabetic human subjects. The results showed that Grewia asiatica fruit has low GI value of 5.34 with modest hypoglycemic activity. Luminol-enhanced chemiluminescence assay was carried out to determine the production of reactive oxygen species (ROS) in the oxidative burst activity of whole blood. ROS production was found to be significantly affected, having the 78.3, 58.6 and 30.8% when the subjects were fed with D-glucose, mixture of D-glucose and Grewia asiatica fruit and Grewia asiatica fruit alone respectively as compared to the control. The aqueous, methanolic and butanolic extracts of Grewia asiatica fruits were found to produce a stimulatory effect on ROS production however; the chloroform, hexane and ethanol-acetate extracted exerted significant inhibitory effect. These results demonstrated that Grewia asiatica fruit has desirable effects on blood glucose metabolism manifested as low glycemic response and modulation of ROS production.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalPakistan Journal of Pharmaceutical Sciences
Volume26
Issue number1
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Grewia
Glycemic Index
Phagocytosis
Fruit
Healthy Volunteers
Reactive Oxygen Species
Glucose
Luminol
Respiratory Burst
Hexanes
Traditional Medicine
Chloroform
Luminescence
Hypoglycemic Agents
Blood Glucose
Acetates
Ethanol
Color

Keywords

  • Blood glucose level
  • Glycemic response
  • Nutraceuticals
  • Reactive oxygen species

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Mohammed Ahmed Hassan, O. M., Ahmed, A., Khalid, A. S., Jan, S., Siddiqui, A. A., Perveen, S., & Azim, M. K. (2013). Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. Pakistan Journal of Pharmaceutical Sciences, 26(1), 85-89.

Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. / Mohammed Ahmed Hassan, Osman Mesaik; Ahmed, Asif; Khalid, Ahmed Shukralla; Jan, Saleem; Siddiqui, Afaq Ahmed; Perveen, Shahida; Azim, Muhammad Kamran.

In: Pakistan Journal of Pharmaceutical Sciences, Vol. 26, No. 1, 01.2013, p. 85-89.

Research output: Contribution to journalArticle

Mohammed Ahmed Hassan, OM, Ahmed, A, Khalid, AS, Jan, S, Siddiqui, AA, Perveen, S & Azim, MK 2013, 'Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects', Pakistan Journal of Pharmaceutical Sciences, vol. 26, no. 1, pp. 85-89.
Mohammed Ahmed Hassan OM, Ahmed A, Khalid AS, Jan S, Siddiqui AA, Perveen S et al. Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. Pakistan Journal of Pharmaceutical Sciences. 2013 Jan;26(1):85-89.
Mohammed Ahmed Hassan, Osman Mesaik ; Ahmed, Asif ; Khalid, Ahmed Shukralla ; Jan, Saleem ; Siddiqui, Afaq Ahmed ; Perveen, Shahida ; Azim, Muhammad Kamran. / Effect of Grewia asiatica fruit on glycemic index and phagocytosis tested in healthy human subjects. In: Pakistan Journal of Pharmaceutical Sciences. 2013 ; Vol. 26, No. 1. pp. 85-89.
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