Effect of gamma radiation on amino acid based vesicle carrying radiosensitizer

Translated title of the contribution: Effect of gamma radiation on amino acid based vesicle carrying radiosensitizer

Nur Ratasha Alia Md Rosli, Faizal K.P. Kunchi Mohamed, Muhammad Amir Syafiq Md Sah, Irman Abdul Rahman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vesicles has been developed and studied to be used as a medium to transport radiosensitizer in treating cancer cells by increasing its sensitivity effectively towards the radiation given during radiotherapy. This study was conducted to investigate the effect of gamma radiation on amino acid-based vesicle carrying radiosensitizer. Amino acid based vesicles carrying radiosensitizer were synthesized using sonication method with sodium N-lauroylsarcosinate hydrate and decanol being the primary surfactant, while hydrogen peroxide and sodium hyaluronate as the encapsulated radiosensitizer. The synthesized vesicle was then irradiated at radiation doses equilvalent to those given during radiotherapy. Irradiated vesicle carrying radiosensitizer were then charac terized using Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) and Polarized Light Microscope. Results obtained shows that there were no significant changes in morphology and molecular conformation of the synthesized vesicle after irradiation. Even at higher radiation dose of 100 Gray and 200 Gray, the results remained unchanged. This indicates that the synthesized vesicle carrying radiosensitizer is morphologically and spectroscopically stable even at high radiation doses.

Original languageUndefined/Unknown
Pages (from-to)555-561
Number of pages7
JournalMalaysian Journal of Analytical Sciences
Volume18
Issue number3
Publication statusPublished - 2014

Fingerprint

Gamma rays
Dosimetry
Radiotherapy
Amino Acids
Sonication
Hyaluronic Acid
Light polarization
Hydrates
Surface-Active Agents
Hydrogen Peroxide
Conformations
Microscopes
Sodium
Cells
Irradiation
Transmission electron microscopy
Radiation
sarkosyl

Keywords

  • Amino acid based vesicle
  • Cancer
  • Radiation
  • Radiosensitizer
  • Radiotherapy

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Effect of gamma radiation on amino acid based vesicle carrying radiosensitizer. / Md Rosli, Nur Ratasha Alia; K.P. Kunchi Mohamed, Faizal; Md Sah, Muhammad Amir Syafiq; Abdul Rahman, Irman.

In: Malaysian Journal of Analytical Sciences, Vol. 18, No. 3, 2014, p. 555-561.

Research output: Contribution to journalArticle

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AU - Md Rosli, Nur Ratasha Alia

AU - K.P. Kunchi Mohamed, Faizal

AU - Md Sah, Muhammad Amir Syafiq

AU - Abdul Rahman, Irman

PY - 2014

Y1 - 2014

N2 - Vesicles has been developed and studied to be used as a medium to transport radiosensitizer in treating cancer cells by increasing its sensitivity effectively towards the radiation given during radiotherapy. This study was conducted to investigate the effect of gamma radiation on amino acid-based vesicle carrying radiosensitizer. Amino acid based vesicles carrying radiosensitizer were synthesized using sonication method with sodium N-lauroylsarcosinate hydrate and decanol being the primary surfactant, while hydrogen peroxide and sodium hyaluronate as the encapsulated radiosensitizer. The synthesized vesicle was then irradiated at radiation doses equilvalent to those given during radiotherapy. Irradiated vesicle carrying radiosensitizer were then charac terized using Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) and Polarized Light Microscope. Results obtained shows that there were no significant changes in morphology and molecular conformation of the synthesized vesicle after irradiation. Even at higher radiation dose of 100 Gray and 200 Gray, the results remained unchanged. This indicates that the synthesized vesicle carrying radiosensitizer is morphologically and spectroscopically stable even at high radiation doses.

AB - Vesicles has been developed and studied to be used as a medium to transport radiosensitizer in treating cancer cells by increasing its sensitivity effectively towards the radiation given during radiotherapy. This study was conducted to investigate the effect of gamma radiation on amino acid-based vesicle carrying radiosensitizer. Amino acid based vesicles carrying radiosensitizer were synthesized using sonication method with sodium N-lauroylsarcosinate hydrate and decanol being the primary surfactant, while hydrogen peroxide and sodium hyaluronate as the encapsulated radiosensitizer. The synthesized vesicle was then irradiated at radiation doses equilvalent to those given during radiotherapy. Irradiated vesicle carrying radiosensitizer were then charac terized using Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FTIR) and Polarized Light Microscope. Results obtained shows that there were no significant changes in morphology and molecular conformation of the synthesized vesicle after irradiation. Even at higher radiation dose of 100 Gray and 200 Gray, the results remained unchanged. This indicates that the synthesized vesicle carrying radiosensitizer is morphologically and spectroscopically stable even at high radiation doses.

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