Effect of enzymatic hydrolysis on Angiotensin converting enzyme (ACE) inhibitory activity in swiftlet saliva

M. H. Nurfatin, I. K. Etty Syarmila, D. Nur 'Aliah, Zalifah Mohd Kasim, Abd. Salam Babji, Mohd. Khan Ayob

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Angiotensin I-converting enzyme (ACE) plays an important role in reducing blood pressure and gives an anti-hypertensive effect. Inhibition of ACE mainly results in an overall antihypertensive effect. The objectives of this study were to determine the ACE inhibition activity in edible bird nest hydrolysates and the effect of different hydrolysis time of 30, 60, 90, 120, 180 and 240 minutes. Edible bird nest protein was hydrolysed by enzymatic hydrolysis with alcalase and papain to obtain ACE inhibitory peptides. The results suggested that 60 minutes of hydrolysis time using alcalase contributed to the best ACE inhibitory activity (IC50 = 0.02mg protein/ml) which shows edible bird nest protein hydrolysate to be a potent ACE inhibitor that may be used to decrease blood pressure.

Original languageEnglish
Pages (from-to)141-146
Number of pages6
JournalInternational Food Research Journal
Volume23
Issue number1
Publication statusPublished - 2016

Fingerprint

Apodidae
peptidyl-dipeptidase A
Peptidyl-Dipeptidase A
enzymatic hydrolysis
saliva
Saliva
Hydrolysis
Avian Proteins
Subtilisins
antihypertensive effect
subtilisin
Antihypertensive Agents
blood pressure
hydrolysis
Blood Pressure
Protein Hydrolysates
Papain
enzyme inhibition
papain
protein hydrolysates

Keywords

  • Alcalase
  • Angiotensin converting enzyme (ACE)
  • Edible bird nest
  • Enzymatic hydrolysis
  • Papain

ASJC Scopus subject areas

  • Food Science

Cite this

Effect of enzymatic hydrolysis on Angiotensin converting enzyme (ACE) inhibitory activity in swiftlet saliva. / Nurfatin, M. H.; Etty Syarmila, I. K.; Nur 'Aliah, D.; Mohd Kasim, Zalifah; Babji, Abd. Salam; Ayob, Mohd. Khan.

In: International Food Research Journal, Vol. 23, No. 1, 2016, p. 141-146.

Research output: Contribution to journalArticle

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