Effect of age, weight, race and sex on blood pressure and erythrocyte sodium pump characteristics

N. Adeeb, S. H. Ton, N. Muslim

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    In order to examine whether erythrocyte membrane handling of sodium is influenced by factors other than hypertension, measurements of red cell sodium transport were studied in one hundred normotensive volunteers. Erythrocyte sodium content was found to increase with increasing age, body weight and mean arterial pressure (MAP). It is also significantly correlated with age, body weight and MAP. Total sodium efflux was found to be reduced and negatively correlated with age and body weight. A reduction in ouabain-sensitive sodium efflux was also observed with increasing age and body weight. In males, the rate of ouabain-sensitive sodium efflux is higher than in females. Race was found to have no effect on erythrocyte electrolyte content and cationic flux rates of subjects. These data suggest that when studies in hypertension are going to be carried out, control subjects carefully matched for age, body weight and sex should be used if confounding results are not to be obtained.

    Original languageEnglish
    Pages (from-to)1115-1134
    Number of pages20
    JournalClinical and Experimental Hypertension
    VolumeA12
    Issue number6
    DOIs
    Publication statusPublished - 1990

    Fingerprint

    Sodium-Potassium-Exchanging ATPase
    Erythrocytes
    Sodium
    Blood Pressure
    Weights and Measures
    Body Weight
    Ouabain
    Arterial Pressure
    Hypertension
    Erythrocyte Membrane
    Electrolytes
    Volunteers

    Keywords

    • Biological transport
    • Blood pressure
    • Cations
    • Erythrocytes
    • Weight

    ASJC Scopus subject areas

    • Internal Medicine
    • Physiology

    Cite this

    Effect of age, weight, race and sex on blood pressure and erythrocyte sodium pump characteristics. / Adeeb, N.; Ton, S. H.; Muslim, N.

    In: Clinical and Experimental Hypertension, Vol. A12, No. 6, 1990, p. 1115-1134.

    Research output: Contribution to journalArticle

    @article{3edcaeb32cc24004bccf2993f88a8308,
    title = "Effect of age, weight, race and sex on blood pressure and erythrocyte sodium pump characteristics",
    abstract = "In order to examine whether erythrocyte membrane handling of sodium is influenced by factors other than hypertension, measurements of red cell sodium transport were studied in one hundred normotensive volunteers. Erythrocyte sodium content was found to increase with increasing age, body weight and mean arterial pressure (MAP). It is also significantly correlated with age, body weight and MAP. Total sodium efflux was found to be reduced and negatively correlated with age and body weight. A reduction in ouabain-sensitive sodium efflux was also observed with increasing age and body weight. In males, the rate of ouabain-sensitive sodium efflux is higher than in females. Race was found to have no effect on erythrocyte electrolyte content and cationic flux rates of subjects. These data suggest that when studies in hypertension are going to be carried out, control subjects carefully matched for age, body weight and sex should be used if confounding results are not to be obtained.",
    keywords = "Biological transport, Blood pressure, Cations, Erythrocytes, Weight",
    author = "N. Adeeb and Ton, {S. H.} and N. Muslim",
    year = "1990",
    doi = "10.3109/10641969009073522",
    language = "English",
    volume = "A12",
    pages = "1115--1134",
    journal = "Clinical and Experimental Hypertension",
    issn = "1064-1963",
    publisher = "Informa Healthcare",
    number = "6",

    }

    TY - JOUR

    T1 - Effect of age, weight, race and sex on blood pressure and erythrocyte sodium pump characteristics

    AU - Adeeb, N.

    AU - Ton, S. H.

    AU - Muslim, N.

    PY - 1990

    Y1 - 1990

    N2 - In order to examine whether erythrocyte membrane handling of sodium is influenced by factors other than hypertension, measurements of red cell sodium transport were studied in one hundred normotensive volunteers. Erythrocyte sodium content was found to increase with increasing age, body weight and mean arterial pressure (MAP). It is also significantly correlated with age, body weight and MAP. Total sodium efflux was found to be reduced and negatively correlated with age and body weight. A reduction in ouabain-sensitive sodium efflux was also observed with increasing age and body weight. In males, the rate of ouabain-sensitive sodium efflux is higher than in females. Race was found to have no effect on erythrocyte electrolyte content and cationic flux rates of subjects. These data suggest that when studies in hypertension are going to be carried out, control subjects carefully matched for age, body weight and sex should be used if confounding results are not to be obtained.

    AB - In order to examine whether erythrocyte membrane handling of sodium is influenced by factors other than hypertension, measurements of red cell sodium transport were studied in one hundred normotensive volunteers. Erythrocyte sodium content was found to increase with increasing age, body weight and mean arterial pressure (MAP). It is also significantly correlated with age, body weight and MAP. Total sodium efflux was found to be reduced and negatively correlated with age and body weight. A reduction in ouabain-sensitive sodium efflux was also observed with increasing age and body weight. In males, the rate of ouabain-sensitive sodium efflux is higher than in females. Race was found to have no effect on erythrocyte electrolyte content and cationic flux rates of subjects. These data suggest that when studies in hypertension are going to be carried out, control subjects carefully matched for age, body weight and sex should be used if confounding results are not to be obtained.

    KW - Biological transport

    KW - Blood pressure

    KW - Cations

    KW - Erythrocytes

    KW - Weight

    UR - http://www.scopus.com/inward/record.url?scp=0024997129&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0024997129&partnerID=8YFLogxK

    U2 - 10.3109/10641969009073522

    DO - 10.3109/10641969009073522

    M3 - Article

    VL - A12

    SP - 1115

    EP - 1134

    JO - Clinical and Experimental Hypertension

    JF - Clinical and Experimental Hypertension

    SN - 1064-1963

    IS - 6

    ER -