Abstract
Background: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. Methods: A total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output. Results: Our data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation. Conclusion: This study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.
| Original language | English |
|---|---|
| Pages (from-to) | S43-S62 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 70 |
| Issue number | s1 |
| DOIs | |
| Publication status | Published - 1 Jan 2019 |
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Keywords
- Aging
- cognitive function
- Malay population
- protein profiling
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency. / Bakar, Zulzikry Hafiz Abu; Ahmad Damanhuri, Mohd Hanafi; Makpol, Suzana; Wan Kamaruddin, Wan Mohd Aizat; Sani, Nur Fathiah Abdul; Hamzah, Ahmad Imran Zaydi Amir; Aripin, Khairun Nain Nor; Rani, Mohd Dzulkhairi Mohd; Noh, Nor Azila; Razali, Rosdinom; Mazlan, Musalmah; Abdul Hamid, Hamzaini; Mohamad, Mazlyfarina; Ngah, Wan Zurinah Wan.
In: Journal of Alzheimer's Disease, Vol. 70, No. s1, 01.01.2019, p. S43-S62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency
AU - Bakar, Zulzikry Hafiz Abu
AU - Ahmad Damanhuri, Mohd Hanafi
AU - Makpol, Suzana
AU - Wan Kamaruddin, Wan Mohd Aizat
AU - Sani, Nur Fathiah Abdul
AU - Hamzah, Ahmad Imran Zaydi Amir
AU - Aripin, Khairun Nain Nor
AU - Rani, Mohd Dzulkhairi Mohd
AU - Noh, Nor Azila
AU - Razali, Rosdinom
AU - Mazlan, Musalmah
AU - Abdul Hamid, Hamzaini
AU - Mohamad, Mazlyfarina
AU - Ngah, Wan Zurinah Wan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. Methods: A total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output. Results: Our data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation. Conclusion: This study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.
AB - Background: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. Methods: A total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output. Results: Our data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation. Conclusion: This study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.
KW - Aging
KW - cognitive function
KW - Malay population
KW - protein profiling
UR - http://www.scopus.com/inward/record.url?scp=85071312282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071312282&partnerID=8YFLogxK
U2 - 10.3233/JAD-180511
DO - 10.3233/JAD-180511
M3 - Article
C2 - 30594926
AN - SCOPUS:85071312282
VL - 70
SP - S43-S62
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - s1
ER -