Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency

Zulzikry Hafiz Abu Bakar, Mohd Hanafi Ahmad Damanhuri, Suzana Makpol, Wan Mohd Aizat Wan Kamaruddin, Nur Fathiah Abdul Sani, Ahmad Imran Zaydi Amir Hamzah, Khairun Nain Nor Aripin, Mohd Dzulkhairi Mohd Rani, Nor Azila Noh, Rosdinom Razali, Musalmah Mazlan, Hamzaini Abdul Hamid, Mazlyfarina Mohamad, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on the protein profile of Malay individuals and its association with cognitive competency. Methods: A total of 160 individuals were recruited and grouped accordingly. Cognitive competency of each subject was assessed with several neuropsychological tests. Plasma samples were collected and analyzed with Q Exactive HF Orbitrap. Proteins were identified and quantitated with MaxQuant and further analyzed with Perseus to determine differentially expressed proteins. PANTHER, Reactome, and STRING were applied for bioinformatics output. Results: Our data showed that the Malay individuals are vulnerable to the deterioration of cognitive function with aging, and most of the proteins were differentially expressed in concordance. Several physiological components and pathways were shown to be involved, giving a hint of a promising interpretation on the induction of aging toward the state of the Malays' cognitive function. Nevertheless, some proteins have shown a considerable interaction with the generated protein network, which provides a direction of focus for further investigation. Conclusion: This study demonstrated notable changes in the expression of several proteins as age increased. These changes provide a promising platform for understanding the biochemical factors affecting cognitive function in the Malay population. The exhibited network of protein-protein interaction suggests the possibility of implementing regulatory intervention in ameliorating Malay cognitive function.

Original languageEnglish
Pages (from-to)S43-S62
JournalJournal of Alzheimer's Disease
Volume70
Issue numbers1
DOIs
Publication statusPublished - 1 Jan 2019

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Cognition
Proteins
Neuropsychological Tests
Computational Biology
Population
Demography
Psychology

Keywords

  • Aging
  • cognitive function
  • Malay population
  • protein profiling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency. / Bakar, Zulzikry Hafiz Abu; Ahmad Damanhuri, Mohd Hanafi; Makpol, Suzana; Wan Kamaruddin, Wan Mohd Aizat; Sani, Nur Fathiah Abdul; Hamzah, Ahmad Imran Zaydi Amir; Aripin, Khairun Nain Nor; Rani, Mohd Dzulkhairi Mohd; Noh, Nor Azila; Razali, Rosdinom; Mazlan, Musalmah; Abdul Hamid, Hamzaini; Mohamad, Mazlyfarina; Ngah, Wan Zurinah Wan.

In: Journal of Alzheimer's Disease, Vol. 70, No. s1, 01.01.2019, p. S43-S62.

Research output: Contribution to journalArticle

Bakar, Zulzikry Hafiz Abu ; Ahmad Damanhuri, Mohd Hanafi ; Makpol, Suzana ; Wan Kamaruddin, Wan Mohd Aizat ; Sani, Nur Fathiah Abdul ; Hamzah, Ahmad Imran Zaydi Amir ; Aripin, Khairun Nain Nor ; Rani, Mohd Dzulkhairi Mohd ; Noh, Nor Azila ; Razali, Rosdinom ; Mazlan, Musalmah ; Abdul Hamid, Hamzaini ; Mohamad, Mazlyfarina ; Ngah, Wan Zurinah Wan. / Effect of Age on the Protein Profile of Healthy Malay Adults and its Association with Cognitive Function Competency. In: Journal of Alzheimer's Disease. 2019 ; Vol. 70, No. s1. pp. S43-S62.
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AU - Sani, Nur Fathiah Abdul

AU - Hamzah, Ahmad Imran Zaydi Amir

AU - Aripin, Khairun Nain Nor

AU - Rani, Mohd Dzulkhairi Mohd

AU - Noh, Nor Azila

AU - Razali, Rosdinom

AU - Mazlan, Musalmah

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