Effect of acetylcholine and morphine on bronchial smooth muscle contraction and its modulation by steroid hormones

Nabishah Mohamad, P. B. Morat, B. A K Khalid, B. A. Kadir

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

1. The effects of corticosteroid pretreatment on acetylcholine (ACH)-induced contraction of bronchial smooth muscle (BSM) were studied. 2. ACH dose-response curves for dexamethasone (DM)- and corticosterone (B)-treated but not deoxycorticosterone (DOC)-treated BSM were significantly shifted to the right; this provides evidence that glucocorticoid treatment reduced the sensitivity of BSM to ACH. 3. Morphine enhanced BSM contraction in response to ACH by 20%. DM suppressed this enhancement. 4. These findings correlated well with the reduction of muscarinic receptor numbers in BSM by glucocorticoids in our previous study. In addition, glucocorticoids reduced the sensitivity of BSM to opioids.

Original languageEnglish
Pages (from-to)841-847
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume17
Issue number12
Publication statusPublished - 1990

Fingerprint

Muscle Contraction
Morphine
Acetylcholine
Smooth Muscle
Steroids
Hormones
Glucocorticoids
Dexamethasone
Desoxycorticosterone
Muscarinic Receptors
Corticosterone
Opioid Analgesics
Adrenal Cortex Hormones

Keywords

  • Bronchial contraction
  • Corticosterone
  • Deoxycorticosterone
  • Dexamethasone
  • Morphine

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Effect of acetylcholine and morphine on bronchial smooth muscle contraction and its modulation by steroid hormones. / Mohamad, Nabishah; Morat, P. B.; Khalid, B. A K; Kadir, B. A.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 17, No. 12, 1990, p. 841-847.

Research output: Contribution to journalArticle

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