E-cadherin expression correlates with histologic type but not tumour grade in invasive breast cancer

Nurismah Md Isa, O. Noriah, M. Y. Suryati, N. A. Sharifah

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The traditional classification of infiltrating breast carcinomas into ductal and lobular can be diagnostically challenging in a small proportion of cases with equivocal histological features and in in-situ lesions with overlapping features. Distinguishing between the infiltrating ductal (IDC) and lobular (ILC) carcinomas is clinically important because of the different pattern of systemic metastases and prognostic evaluation. E-cadherin is a potentially useful immunohistochemical marker which may serve to differentiate between the two tumour types. We therefore studied E-cadherin expression in 32 cases of breast carcinomas comprising 16 IDCs and 16 ILCs. The correlation between E-cadherin expression and the histological grade of IDCs was also analysed. Our results showed complete loss of E-cadherin expression in all ILCs, while the IDCs consistently showed variable E-cadherin positivity. No significant correlation was found between E-cadherin expression and the histological grade of IDCs. We conclude from this study that E-cadherin is a useful marker to differentiate between IDC and ILC of the breast. A larger study of IDCs is now needed to further evaluate the correlation between E-cadherin and tumour grade to estimate its prognostic potential.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalAsian Pacific Journal of Cancer Prevention
Volume9
Issue number4
Publication statusPublished - 2008

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Cadherins
Breast Neoplasms
Neoplasms
Carcinoma, Ductal, Breast
Lobular Carcinoma
Breast
Neoplasm Metastasis

Keywords

  • E-cadherin
  • Infiltrating ductal carcinoma
  • Infiltrating lobular carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

E-cadherin expression correlates with histologic type but not tumour grade in invasive breast cancer. / Md Isa, Nurismah; Noriah, O.; Suryati, M. Y.; Sharifah, N. A.

In: Asian Pacific Journal of Cancer Prevention, Vol. 9, No. 4, 2008, p. 699-702.

Research output: Contribution to journalArticle

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