Dydrogesterone in threatened abortion

Pregnancy outcome

Mohd Hashim Omar, M. K. Mashita, Pei Shan Lim, M. A. Jamil

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: To determine whether therapy with dydrogesterone in threatened abortion during the first trimester of pregnancy will improve pregnancy outcome. Design: Prospective open study. Subjects: Pregnant women presenting to the obstetric and gynaecology clinic admitting center with vaginal bleeding before 13 weeks gestation were evaluated for entry into the study. Women were excluded if they had a history of recurrent miscarriage. Method: Eligible subjects were randomized to receive either dydrogesterone 40 mg stat dose followed by 10 mg twice a day for one week or conservative therapy. Results: One hundred and 54 women were recruited. There was no statistically significant differences between the two groups with regard to pre-treatment status. The continuing pregnancy success rate was significantly (p = 0.037) higher in women treated with dydrogesterone (95.9%) compared with women who received conservative treatment (86.3%). The odds ratio of the success rate between dydrogesterone treatment and non-treatment was 3.773 (95% confidence interval: 1.009-14.108). Conclusion: Corpus luteal support with dydrogesterone has been shown to reduce the incidence of pregnancy loss in threatened abortion during the first trimester in women without a history of recurrent abortion.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume97
Issue number5
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Dydrogesterone
Threatened Abortion
Pregnancy Outcome
Habitual Abortion
First Pregnancy Trimester
Gynecology
History
Obstetrics
Pregnancy
Uterine Hemorrhage
Corpus Luteum
Pregnancy Rate
Pregnant Women
Therapeutics
Odds Ratio
Prospective Studies
Confidence Intervals
Incidence

Keywords

  • Dydrogesterone
  • Luteal support
  • Pregnancy
  • Threatened abortion

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Dydrogesterone in threatened abortion : Pregnancy outcome. / Omar, Mohd Hashim; Mashita, M. K.; Lim, Pei Shan; Jamil, M. A.

In: Journal of Steroid Biochemistry and Molecular Biology, Vol. 97, No. 5, 12.2005, p. 421-425.

Research output: Contribution to journalArticle

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