Duration of detection of anti-BmR1 IgG4 antibodies after mass-drug administration (MDA) in Sarawak, Malaysia

R. Noordin, J. Muhi, Zulkarnain Md Idris, N. Arifin, A. Kiyu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The detection rates of brugian filariasis in three regions of Sarawak namely Central, North and South after three courses of mass drug administration (MDA) from year 2004 to 2006 was investigated. A recombinant BmR1 antigen-based IgG4 detection test, named Brugia Rapid and night blood smear for microfilaria (mf) detection were used. All three regions recorded a sharp fall in mf positive rates after a year post-MDA. Meanwhile Brugia Rapid positive rates declined more gradually to 3.8% and 5.6% of the pre-MDA levels in the Central and North regions, respectively. This study showed that in filariasis endemic areas in Sarawak, anti-filarial IgG4 antibodies to BmR1, as detected by the Brugia Rapid test, were positive for one to two years after mf disappearance.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalTropical Biomedicine
Volume29
Issue number1
Publication statusPublished - Mar 2012
Externally publishedYes

Fingerprint

Brugia
Microfilariae
Malaysia
Filariasis
Immunoglobulin G
Antibodies
Pharmaceutical Preparations
Antigens

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Duration of detection of anti-BmR1 IgG4 antibodies after mass-drug administration (MDA) in Sarawak, Malaysia. / Noordin, R.; Muhi, J.; Md Idris, Zulkarnain; Arifin, N.; Kiyu, A.

In: Tropical Biomedicine, Vol. 29, No. 1, 03.2012, p. 191-196.

Research output: Contribution to journalArticle

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