Drug resistance and susceptibility of mycobacterium tuberculosis identified at University Kebangsaan Malaysia medical centre

Sharifah Azura Salleh, Salasawati Hussin, Md. Mostafizur Rahman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: The prime objective of the study was to evaluate drug resistance and susceptibility of Mycobacterium tuberculosis isolated at University Kebangsaan Malaysia Medical Centre. Methodology: A total number of 726 specimens in the form of sputum and bronchial lavage obtained from patients suspected to tuberculosis were analysed for confirmatory identification and antibiotic susceptibility testing. The bacteria was identified initially by culture and staining and finally by BDProbeTec™ ET Mycobacteria kits (2008). All Mycobacterium tuberculosis isolates were subjected to antibiotic susceptibility against streptomycin, isoniazid, rifampicin and ethambutol using BACTEC™ MGIT™ 960 system. Results: Out of 726 specimens 16 (32.65%) were identified as mono drug resistance 7 (14.29%) as poly drug resistance, 4 (8.16%) as multi-drug resistance (MDR-TB). Identified TB bacteria were analysed in the light of sources of samples where brief history of the patients' age, gender and community noted. Conclusion: Bacteriologic testing with antibiotic sensitivity, standardized treatment with supervision and patient support, provision and management of the drugs used in treatment are necessary for effective treatment of tuberculosis.

Original languageEnglish
Pages (from-to)1107-1111
Number of pages5
JournalPakistan Journal of Medical Sciences
Volume27
Issue number5
Publication statusPublished - 2011

Fingerprint

Malaysia
Mycobacterium tuberculosis
Drug Resistance
Anti-Bacterial Agents
Tuberculosis
Bacteria
Ethambutol
Isoniazid
Multiple Drug Resistance
Bronchoalveolar Lavage
Streptomycin
Rifampin
Mycobacterium
Sputum
Therapeutics
Staining and Labeling
Pharmaceutical Preparations

Keywords

  • MDR-TB
  • Mycobacterium tuberculosis
  • Resistance
  • Susceptibility
  • XDR-TB

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Drug resistance and susceptibility of mycobacterium tuberculosis identified at University Kebangsaan Malaysia medical centre. / Salleh, Sharifah Azura; Hussin, Salasawati; Rahman, Md. Mostafizur.

In: Pakistan Journal of Medical Sciences, Vol. 27, No. 5, 2011, p. 1107-1111.

Research output: Contribution to journalArticle

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