Does Bisphenol A contribute to autism spectrum disorder?

Zaleha Md Nor, Siti Norbayah Yusof, Hasanain Faisal Ghazi, Zaleha Md Isa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Autism Spectrum Disorder (ASD) includes a range of conditions classified as neurodevelopmental disorders that have an onset from infancy. Multiple factors have been identified as causes for the autism spectrum disorder; however, the cascade of the disease is still not clearly defined. An increasing number of cases have been reported globally, for instance in US, UK, Canada and Australia. Environmental factors were suspected to be one of the causes. Bisphenol A (BPA) is an Endocrine Disruptor Compound (EDC) and used primarily as a monomer for the production of polycarbonate and epoxy resins, especially in feeding bottles for infants. Ongoing discussions are currently in progress on the reported low-dose effects of BPA, particularly its neurodevelopmental and behavioural effects. Many countries have banned the usage of BPA due to its harmful effects on children. This review aims at presenting an overview of the association between exposure to BPA and the neurobehavioural changes it triggers in children. Articles were obtained from the Science Direct and ProQuest search engines. The keywords used in the search were 'BPA' or 'bisphenol A' and 'autism'. Fourty-seven articles were shortlisted, of which only five that fulfilled the requisite criteria were selected for review. All of them were cohort studies. Overall, an association has been established between prenatal and childhood exposure to BPA and neurobehavioural changes. The exposure during pregnancy was observed to have a greater impact on children. Earlier exposure during the prenatal period resulted in stronger associations. However, no association was found between BPA concentration of the child and neurobehavioural outcomes.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalCurrent Topics in Toxicology
Volume10
Publication statusPublished - 2014

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polycarbonate
Bottle Feeding
Epoxy Resins
Endocrine Disruptors
Search Engine
Autism Spectrum Disorder
bisphenol A
Bottles
Autistic Disorder
Search engines
Canada
Cohort Studies
Monomers
Pregnancy
Neurodevelopmental Disorders

Keywords

  • Autism spectrum disorder (ASD)
  • Bisphenol A (BPA)
  • Children
  • Neurobehaviour

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Does Bisphenol A contribute to autism spectrum disorder? / Nor, Zaleha Md; Yusof, Siti Norbayah; Ghazi, Hasanain Faisal; Md Isa, Zaleha.

In: Current Topics in Toxicology, Vol. 10, 2014, p. 63-70.

Research output: Contribution to journalArticle

Nor, Zaleha Md ; Yusof, Siti Norbayah ; Ghazi, Hasanain Faisal ; Md Isa, Zaleha. / Does Bisphenol A contribute to autism spectrum disorder?. In: Current Topics in Toxicology. 2014 ; Vol. 10. pp. 63-70.
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