DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin

Clive Morris, Rahmah Mohamed, Martin F. Lavin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A marked increase in sensitivity to bleomycin was observed in two ataxia telangiectasia (AT) lymphoblastoid cell lines compared to that in cell lines from two normal individuals. This sensitivity was obtained at two different concentrations of bleomycin. While normal cells showed a rapid recovery of ability to divide, there was no indication of such a recovery in AT cells up to 120 h after bleomycin treatment. A similar level of breakage of DNA occurred in both cell types after incubation with bleomycin. The rate of repair of these breaks was also the same. DNA synthesis was found to be more resistant to bleomycin in AT cells than in control cells. The latter data are in keeping with results previously obtained using ionizing radiation.

Original languageEnglish
Pages (from-to)67-74
Number of pages8
JournalMutation Research DNA Repair Reports
Volume112
Issue number2
DOIs
Publication statusPublished - 1983
Externally publishedYes

Fingerprint

Ataxia Telangiectasia
Bleomycin
DNA Replication
DNA Repair
Cell Line
DNA
Ionizing Radiation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin. / Morris, Clive; Mohamed, Rahmah; Lavin, Martin F.

In: Mutation Research DNA Repair Reports, Vol. 112, No. 2, 1983, p. 67-74.

Research output: Contribution to journalArticle

Morris, Clive ; Mohamed, Rahmah ; Lavin, Martin F. / DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin. In: Mutation Research DNA Repair Reports. 1983 ; Vol. 112, No. 2. pp. 67-74.
@article{d54ec58b3c65454b9e3d69d4b36e83cc,
title = "DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin",
abstract = "A marked increase in sensitivity to bleomycin was observed in two ataxia telangiectasia (AT) lymphoblastoid cell lines compared to that in cell lines from two normal individuals. This sensitivity was obtained at two different concentrations of bleomycin. While normal cells showed a rapid recovery of ability to divide, there was no indication of such a recovery in AT cells up to 120 h after bleomycin treatment. A similar level of breakage of DNA occurred in both cell types after incubation with bleomycin. The rate of repair of these breaks was also the same. DNA synthesis was found to be more resistant to bleomycin in AT cells than in control cells. The latter data are in keeping with results previously obtained using ionizing radiation.",
author = "Clive Morris and Rahmah Mohamed and Lavin, {Martin F.}",
year = "1983",
doi = "10.1016/0167-8817(83)90011-1",
language = "English",
volume = "112",
pages = "67--74",
journal = "Mutation Research DNA Repair Reports",
issn = "0167-8817",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - DNA replication and repair in ataxia telangiectasia cells exposed to bleomycin

AU - Morris, Clive

AU - Mohamed, Rahmah

AU - Lavin, Martin F.

PY - 1983

Y1 - 1983

N2 - A marked increase in sensitivity to bleomycin was observed in two ataxia telangiectasia (AT) lymphoblastoid cell lines compared to that in cell lines from two normal individuals. This sensitivity was obtained at two different concentrations of bleomycin. While normal cells showed a rapid recovery of ability to divide, there was no indication of such a recovery in AT cells up to 120 h after bleomycin treatment. A similar level of breakage of DNA occurred in both cell types after incubation with bleomycin. The rate of repair of these breaks was also the same. DNA synthesis was found to be more resistant to bleomycin in AT cells than in control cells. The latter data are in keeping with results previously obtained using ionizing radiation.

AB - A marked increase in sensitivity to bleomycin was observed in two ataxia telangiectasia (AT) lymphoblastoid cell lines compared to that in cell lines from two normal individuals. This sensitivity was obtained at two different concentrations of bleomycin. While normal cells showed a rapid recovery of ability to divide, there was no indication of such a recovery in AT cells up to 120 h after bleomycin treatment. A similar level of breakage of DNA occurred in both cell types after incubation with bleomycin. The rate of repair of these breaks was also the same. DNA synthesis was found to be more resistant to bleomycin in AT cells than in control cells. The latter data are in keeping with results previously obtained using ionizing radiation.

UR - http://www.scopus.com/inward/record.url?scp=0020686706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020686706&partnerID=8YFLogxK

U2 - 10.1016/0167-8817(83)90011-1

DO - 10.1016/0167-8817(83)90011-1

M3 - Article

C2 - 6188043

AN - SCOPUS:0020686706

VL - 112

SP - 67

EP - 74

JO - Mutation Research DNA Repair Reports

JF - Mutation Research DNA Repair Reports

SN - 0167-8817

IS - 2

ER -