DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population

Nur Fathiah Abdul Sani, Mohd Hanafi Ahmad Damanhuri, Ahmad Imran Zaydi Amir Hamzah, Zulzikry Hafiz Abu Bakar, Jen Kit Tan, Khairun Nain Nor Aripin, Mohd Dzulkhairi Mohd Rani, Nor Azila Noh, Nor Aripin Shamaan, Rosdinom Razali, Yasmin Anum Mohd Yusof, Musalmah Mazlan, Suzana Makpol, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

Abstract

Ageing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation.

Original languageEnglish
JournalFree Radical Research
DOIs
Publication statusAccepted/In press - 1 Jan 2018

Fingerprint

DNA Damage
Aging of materials
Oxidation
Oxidative stress
DNA
Malondialdehyde
Cognition
Population
Reproduction
Proteins
Oxidative Stress
Age Groups
Verbal Learning
Biomarkers
Regression analysis
Logistics
Blood Proteins
Logistic Models
Regression Analysis
Cognitive Dysfunction

Keywords

  • ageing
  • cognitive impairment
  • cross-sectional study
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry

Cite this

DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population. / Abdul Sani, Nur Fathiah; Ahmad Damanhuri, Mohd Hanafi; Amir Hamzah, Ahmad Imran Zaydi; Abu Bakar, Zulzikry Hafiz; Tan, Jen Kit; Nor Aripin, Khairun Nain; Mohd Rani, Mohd Dzulkhairi; Noh, Nor Azila; Shamaan, Nor Aripin; Razali, Rosdinom; Mohd Yusof, Yasmin Anum; Mazlan, Musalmah; Makpol, Suzana; Wan Ngah, Wan Zurinah.

In: Free Radical Research, 01.01.2018.

Research output: Contribution to journalArticle

Abdul Sani, NF, Ahmad Damanhuri, MH, Amir Hamzah, AIZ, Abu Bakar, ZH, Tan, JK, Nor Aripin, KN, Mohd Rani, MD, Noh, NA, Shamaan, NA, Razali, R, Mohd Yusof, YA, Mazlan, M, Makpol, S & Wan Ngah, WZ 2018, 'DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population', Free Radical Research. https://doi.org/10.1080/10715762.2018.1506877
Abdul Sani, Nur Fathiah ; Ahmad Damanhuri, Mohd Hanafi ; Amir Hamzah, Ahmad Imran Zaydi ; Abu Bakar, Zulzikry Hafiz ; Tan, Jen Kit ; Nor Aripin, Khairun Nain ; Mohd Rani, Mohd Dzulkhairi ; Noh, Nor Azila ; Shamaan, Nor Aripin ; Razali, Rosdinom ; Mohd Yusof, Yasmin Anum ; Mazlan, Musalmah ; Makpol, Suzana ; Wan Ngah, Wan Zurinah. / DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population. In: Free Radical Research. 2018.
@article{34c7ae34061b4cd583efbf0be644ddca,
title = "DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population",
abstract = "Ageing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88{\%} of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation.",
keywords = "ageing, cognitive impairment, cross-sectional study, Oxidative stress",
author = "{Abdul Sani}, {Nur Fathiah} and {Ahmad Damanhuri}, {Mohd Hanafi} and {Amir Hamzah}, {Ahmad Imran Zaydi} and {Abu Bakar}, {Zulzikry Hafiz} and Tan, {Jen Kit} and {Nor Aripin}, {Khairun Nain} and {Mohd Rani}, {Mohd Dzulkhairi} and Noh, {Nor Azila} and Shamaan, {Nor Aripin} and Rosdinom Razali and {Mohd Yusof}, {Yasmin Anum} and Musalmah Mazlan and Suzana Makpol and {Wan Ngah}, {Wan Zurinah}",
year = "2018",
month = "1",
day = "1",
doi = "10.1080/10715762.2018.1506877",
language = "English",
journal = "Free Radical Research",
issn = "1071-5762",
publisher = "Informa Healthcare",

}

TY - JOUR

T1 - DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population

AU - Abdul Sani, Nur Fathiah

AU - Ahmad Damanhuri, Mohd Hanafi

AU - Amir Hamzah, Ahmad Imran Zaydi

AU - Abu Bakar, Zulzikry Hafiz

AU - Tan, Jen Kit

AU - Nor Aripin, Khairun Nain

AU - Mohd Rani, Mohd Dzulkhairi

AU - Noh, Nor Azila

AU - Shamaan, Nor Aripin

AU - Razali, Rosdinom

AU - Mohd Yusof, Yasmin Anum

AU - Mazlan, Musalmah

AU - Makpol, Suzana

AU - Wan Ngah, Wan Zurinah

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Ageing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation.

AB - Ageing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation.

KW - ageing

KW - cognitive impairment

KW - cross-sectional study

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=85053809363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053809363&partnerID=8YFLogxK

U2 - 10.1080/10715762.2018.1506877

DO - 10.1080/10715762.2018.1506877

M3 - Article

C2 - 30079776

AN - SCOPUS:85053809363

JO - Free Radical Research

JF - Free Radical Research

SN - 1071-5762

ER -