Distribution of HPV genotypes in cervical cancer in multi-ethnic malaysia

Sayyidi Hamzi Abdul Raub, Nurismah Md Isa, Hatta Ahmad Zailani, Baharudin Omar, Mohamad Farouk Abdullah, Wan Anna Mohd Amin, Rushdan Md Noor, Mukarramah Che Ayub, Zainal Abidin, Fauziah Kassim, Visvalingam Vicknesh, Zubaidah Zakaria, Muhammad Amir Kamaluddin, Geok Chin Tan, Sharifah Noor Akmal Syed Husain

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Cervical cancer is the third commonest type of cancer among women in Malaysia. Our aim was to determine the distribution of human papilloma virus (HPV) genotypes in cervical cancer in our multi-ethnic population. Materials and Methods: This was a multicentre study with a total of 280 cases of cervical cancer from 4 referral centres in Malaysia, studied using real-time polymerase chain reaction (qPCR) detection of 12 high risk-HPV genotypes. Results: Overall HPV was detected in 92.5% of cases, in 95.9% of squamous cell carcinomas and 84.3%of adenocarcinomas. The five most prevalent high-risk HPV genotypes were HPV 16 (68.2%), 18 (40%), 58 (10.7%), 33 (10.4%) and 52 (10.4%). Multiple HPV infections were more prevalent (55.7%) than single HPV infections (36.8%). The percentage of HPV positive cases in Chinese, Malays and Indians were 95.5%, 91.9% and 80.0%, respectively. HPV 16 and 18 genotypes were the commonest in all ethnic groups. We found that the percentage of HPV 16 infection was significantly higher in Chinese (75.9%) compared to Malays (63.7%) and Indians (52.0%) (p<0.05), while HPV 18 was significantly higher in Malays (52.6%) compared to Chinese (25.0%) and Indians (28%) (p<0.05). Meanwhile, HPV 33 (17.9%) and 52 (15.2%) were also more commonly detected in the Chinese (p<0.05). Conclusions: This study showed that the distribution of HPV genotype in Malaysia is similar to other Asian countries. Importantly, we found that different ethnic groups in Malaysia have different HPV genotype infection rates, which is a point to consider during the implementation of HPV vaccination.

Original languageEnglish
Pages (from-to)651-656
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number2
DOIs
Publication statusPublished - 2014

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Papillomaviridae
Malaysia
Uterine Cervical Neoplasms
Genotype
Virus Diseases
Ethnic Groups

Keywords

  • Cervical cancer
  • Distribution of HPV
  • HPV genotyping
  • Human papillomavirus
  • Malaysia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Distribution of HPV genotypes in cervical cancer in multi-ethnic malaysia. / Raub, Sayyidi Hamzi Abdul; Md Isa, Nurismah; Zailani, Hatta Ahmad; Omar, Baharudin; Abdullah, Mohamad Farouk; Amin, Wan Anna Mohd; Noor, Rushdan Md; Ayub, Mukarramah Che; Abidin, Zainal; Kassim, Fauziah; Vicknesh, Visvalingam; Zakaria, Zubaidah; Kamaluddin, Muhammad Amir; Tan, Geok Chin; Husain, Sharifah Noor Akmal Syed.

In: Asian Pacific Journal of Cancer Prevention, Vol. 15, No. 2, 2014, p. 651-656.

Research output: Contribution to journalArticle

Raub, SHA, Md Isa, N, Zailani, HA, Omar, B, Abdullah, MF, Amin, WAM, Noor, RM, Ayub, MC, Abidin, Z, Kassim, F, Vicknesh, V, Zakaria, Z, Kamaluddin, MA, Tan, GC & Husain, SNAS 2014, 'Distribution of HPV genotypes in cervical cancer in multi-ethnic malaysia', Asian Pacific Journal of Cancer Prevention, vol. 15, no. 2, pp. 651-656. https://doi.org/10.7314/APJCP.2014.15.2.651
Raub, Sayyidi Hamzi Abdul ; Md Isa, Nurismah ; Zailani, Hatta Ahmad ; Omar, Baharudin ; Abdullah, Mohamad Farouk ; Amin, Wan Anna Mohd ; Noor, Rushdan Md ; Ayub, Mukarramah Che ; Abidin, Zainal ; Kassim, Fauziah ; Vicknesh, Visvalingam ; Zakaria, Zubaidah ; Kamaluddin, Muhammad Amir ; Tan, Geok Chin ; Husain, Sharifah Noor Akmal Syed. / Distribution of HPV genotypes in cervical cancer in multi-ethnic malaysia. In: Asian Pacific Journal of Cancer Prevention. 2014 ; Vol. 15, No. 2. pp. 651-656.
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AU - Noor, Rushdan Md

AU - Ayub, Mukarramah Che

AU - Abidin, Zainal

AU - Kassim, Fauziah

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