Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis

Noor Kamal Al-Qazzaz, Sawal Hamid Md Ali, Siti Anom Ahmad, Md. Shabiul Islam, Javier Escudero

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Stroke survivors are more prone to developing cognitive impairment and dementia. Dementia detection is a challenge for supporting personalized healthcare. This study analyzes the electroencephalogram (EEG) background activity of 5 vascular dementia (VaD) patients, 15 stroke-related patients with mild cognitive impairment (MCI), and 15 control healthy subjects during a working memory (WM) task. The objective of this study is twofold. First, it aims to enhance the discrimination of VaD, stroke-related MCI patients, and control subjects using fuzzy neighborhood preserving analysis with QR-decomposition (FNPAQR); second, it aims to extract and investigate the spectral features that characterize the post-stroke dementia patients compared to the control subjects. Nineteen channels were recorded and analyzed using the independent component analysis and wavelet analysis (ICA−WT) denoising technique. Using ANOVA, linear spectral power including relative powers (RP) and power ratio were calculated to test whether the EEG dominant frequencies were slowed down in VaD and stroke-related MCI patients. Non-linear features including permutation entropy (PerEn) and fractal dimension (FD) were used to test the degree of irregularity and complexity, which was significantly lower in patients with VaD and stroke-related MCI than that in control subjects (ANOVA; p ˂ 0.05). This study is the first to use fuzzy neighborhood preserving analysis with QR-decomposition (FNPAQR) dimensionality reduction technique with EEG background activity of dementia patients. The impairment of post-stroke patients was detected using support vector machine (SVM) and k-nearest neighbors (kNN) classifiers. A comparative study has been performed to check the effectiveness of using FNPAQR dimensionality reduction technique with the SVM and kNN classifiers. FNPAQR with SVM and kNN obtained 91.48 and 89.63% accuracy, respectively, whereas without using the FNPAQR exhibited 70 and 67.78% accuracy for SVM and kNN, respectively, in classifying VaD, stroke-related MCI, and control patients, respectively. Therefore, EEG could be a reliable index for inspecting concise markers that are sensitive to VaD and stroke-related MCI patients compared to control healthy subjects.

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalMedical and Biological Engineering and Computing
DOIs
Publication statusAccepted/In press - 8 Nov 2017

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Signal analysis
Electroencephalography
Support vector machines
Decomposition
Analysis of variance (ANOVA)
Classifiers
Wavelet analysis
Independent component analysis
Fractal dimension
Entropy
Data storage equipment

Keywords

  • Electroencephalography
  • Fractal dimension
  • ICA−WT
  • Mild cognitive impairment
  • Permutation entropy
  • Relative power
  • Vascular dementia

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computer Science Applications

Cite this

Discrimination of stroke-related mild cognitive impairment and vascular dementia using EEG signal analysis. / Al-Qazzaz, Noor Kamal; Md Ali, Sawal Hamid; Ahmad, Siti Anom; Islam, Md. Shabiul; Escudero, Javier.

In: Medical and Biological Engineering and Computing, 08.11.2017, p. 1-21.

Research output: Contribution to journalArticle

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