Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach

Siti Junaidah Ahmad, Mohd Badrin Hanizam Abdul Rahim, Syarul Nataqain Baharum, Mohd Shukri Baba, Noraziah Mohamad Zin

Research output: Contribution to journalArticle

Abstract

Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging "omics" technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia.

Original languageEnglish
Article number2189814
JournalJournal of Tropical Medicine
Volume2017
DOIs
Publication statusPublished - 1 Jan 2017

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Metabolomics
Antimalarials
Biological Products
Malaria
Spectrophotometry
Drug Discovery
Magnetic Resonance Spectroscopy
Pharmaceutical Preparations
Systems Biology
Malaysia
Streptomyces
Gram-Positive Bacteria
Liquid Chromatography
Biological Assay
Gas Chromatography
Anti-Bacterial Agents
Technology
Bacteria
Research
Therapeutics

ASJC Scopus subject areas

  • Parasitology
  • Microbiology

Cite this

Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach. / Ahmad, Siti Junaidah; Abdul Rahim, Mohd Badrin Hanizam; Baharum, Syarul Nataqain; Baba, Mohd Shukri; Mohamad Zin, Noraziah.

In: Journal of Tropical Medicine, Vol. 2017, 2189814, 01.01.2017.

Research output: Contribution to journalArticle

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