Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds

Synthesis, characterization and biological activities

Normah Awang, Ibrahim Baba

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Three new compounds of dibutyltin(IV) with N-alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C 4H 9) 2Sn[S 2CNR(C 6H 11)] 2 (R = CH 3, C 2H 5, i-C 3H 7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm -1, ν(C=S) bands in the region of 978 - 998 cm -1 and ν(Sn-S) bands in the region of 375 - 389 cm -1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C 4H 9) 2Sn[S 2CN(i-C 3H 7)(C 6H 11)] 2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD 50 values lower than 1.00 μg/mL.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalSains Malaysiana
Volume41
Issue number8
Publication statusPublished - Aug 2012

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Bioactivity
Bacteria
Crystal structure
Tin
Cytotoxicity
Cells
Ligands
Infrared radiation
Atoms
Chemical analysis
di-n-butyltin

Keywords

  • Biological activities
  • Dibutyltin(IV)
  • Dithiocarbamate

ASJC Scopus subject areas

  • General

Cite this

Diorganotin(IV) alkylcyclohexyldithiocarbamate compounds : Synthesis, characterization and biological activities. / Awang, Normah; Baba, Ibrahim.

In: Sains Malaysiana, Vol. 41, No. 8, 08.2012, p. 977-982.

Research output: Contribution to journalArticle

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abstract = "Three new compounds of dibutyltin(IV) with N-alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C 4H 9) 2Sn[S 2CNR(C 6H 11)] 2 (R = CH 3, C 2H 5, i-C 3H 7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm -1, ν(C=S) bands in the region of 978 - 998 cm -1 and ν(Sn-S) bands in the region of 375 - 389 cm -1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10){\AA}. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C 4H 9) 2Sn[S 2CN(i-C 3H 7)(C 6H 11)] 2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD 50 values lower than 1.00 μg/mL.",
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N2 - Three new compounds of dibutyltin(IV) with N-alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C 4H 9) 2Sn[S 2CNR(C 6H 11)] 2 (R = CH 3, C 2H 5, i-C 3H 7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm -1, ν(C=S) bands in the region of 978 - 998 cm -1 and ν(Sn-S) bands in the region of 375 - 389 cm -1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C 4H 9) 2Sn[S 2CN(i-C 3H 7)(C 6H 11)] 2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD 50 values lower than 1.00 μg/mL.

AB - Three new compounds of dibutyltin(IV) with N-alkylcyclohexyldithiocarbamate were successfully synthesized using in situ methods. Elemental analysis data of these complexes were in agreement with the general formula of (C 4H 9) 2Sn[S 2CNR(C 6H 11)] 2 (R = CH 3, C 2H 5, i-C 3H 7). Infrared spectra showed that the thioureide bands, ν(C=N) appeared in the region of 1475 - 1479 cm -1, ν(C=S) bands in the region of 978 - 998 cm -1 and ν(Sn-S) bands in the region of 375 - 389 cm -1. Crystal structure of dibutyltin(IV) ethylcyclohexyldithiocarbamate showed a triclinic system and space group P-1. The crystal structure of the dithiocarbamate ligands were bidentically chelated to the tin atom with Sn-S unsymmetrical: Sn(1)-S(1) = 2.9255(11) and Sn(1)-S(2) = 2.5419(10); Sn(1)-S(3) = 2.8922(9) and Sn(1)-S(4) = 2.5293(10)Å. These compounds were screened for antibacterial activity against four bacteria species using the disc diffusion method. The results showed that (C 4H 9) 2Sn[S 2CN(i-C 3H 7)(C 6H 11)] 2 was mildly active against those three bacteria. Whereas all of these compounds exhibited in vitro cytotoxicity activity toward human leukemic promyelocites HL-60 cell line with CD 50 values lower than 1.00 μg/mL.

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