Differing contributions of classical risk factors to type 2 diabetes in multi-ethnic Malaysian populations

Noraidatulakma Abdullah @ Muda, Nor Azian Abdul Murad, John Attia, Christopher Oldmeadow, Mohd Arman Kamaruddin, Nazihah Abd Jalal, Norliza Ismail, A. Rahman A. Jamal, Rodney J. Scott, Elizabeth G. Holliday

Research output: Contribution to journalArticle

Abstract

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

Original languageEnglish
Article number2813
JournalInternational Journal of Environmental Research and Public Health
Volume15
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Fingerprint

Type 2 Diabetes Mellitus
Life Style
Malaysia
Population
Area Under Curve
Waist-Hip Ratio
ROC Curve
Case-Control Studies
Sleep
Obesity
Logistic Models
Research

Keywords

  • Asian populations
  • Genetic
  • Malaysia
  • Risk factor
  • Rural
  • Type 2 diabetes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

Differing contributions of classical risk factors to type 2 diabetes in multi-ethnic Malaysian populations. / Abdullah @ Muda, Noraidatulakma; Abdul Murad, Nor Azian; Attia, John; Oldmeadow, Christopher; Kamaruddin, Mohd Arman; Jalal, Nazihah Abd; Ismail, Norliza; A. Jamal, A. Rahman; Scott, Rodney J.; Holliday, Elizabeth G.

In: International Journal of Environmental Research and Public Health, Vol. 15, No. 12, 2813, 01.12.2018.

Research output: Contribution to journalArticle

Abdullah @ Muda, Noraidatulakma ; Abdul Murad, Nor Azian ; Attia, John ; Oldmeadow, Christopher ; Kamaruddin, Mohd Arman ; Jalal, Nazihah Abd ; Ismail, Norliza ; A. Jamal, A. Rahman ; Scott, Rodney J. ; Holliday, Elizabeth G. / Differing contributions of classical risk factors to type 2 diabetes in multi-ethnic Malaysian populations. In: International Journal of Environmental Research and Public Health. 2018 ; Vol. 15, No. 12.
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