Differential expression of the angiogenesis growth factors in psoriasis vulgaris

Siaw Cheok Liew, Esha Das-Gupta, Srikumar Chakravarthi, Shew Fung Wong, Nagarajah Lee, Najeeb Safdar, Adawiyah Jamil

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Angiogenesis has been reported to be one of the contributory factors to the pathogenesis of psoriasis vulgaris. This study aims to compare the expression of different angiogenesis growth factors namely (1) the vascular endothelial growth factor (VEGF) subfamily: A, B, C, D and placenta growth factor (PlGF); (2) nerve growth factor (NGF) and (3) von Willebrand factor (vWFr) in the skins of patients with psoriasis vulgaris and non-psoriatic volunteers. Results: Comparative immunohistochemistry study was performed on the paraffin-sectioned psoriatic and healthy skins with the abovementioned markers. VEGF-C (p = 0.016) and NGF (p = 0.027) were expressed intensely in the cases when compared with the controls. The NGF was the only marker that was solely expressed in the cases and absent in all the controls. Conclusion: The NGF (angiogenesis) and VEGF-C (lymphangiogenesis) might play a crucial role in the pathogenesis of psoriasis vulgaris and could be researched further as potential new targeted therapies for psoriasis vulgaris.

Original languageEnglish
Article number201
JournalBMC Research Notes
Volume5
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Angiogenesis Inducing Agents
Nerve Growth Factor
Psoriasis
Vascular Endothelial Growth Factor C
Intercellular Signaling Peptides and Proteins
Skin
Neurotrophin 3
von Willebrand Factor
Lymphangiogenesis
Paraffin
Vascular Endothelial Growth Factor A
Volunteers
Immunohistochemistry
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Liew, S. C., Das-Gupta, E., Chakravarthi, S., Wong, S. F., Lee, N., Safdar, N., & Jamil, A. (2012). Differential expression of the angiogenesis growth factors in psoriasis vulgaris. BMC Research Notes, 5, [201]. https://doi.org/10.1186/1756-0500-5-201

Differential expression of the angiogenesis growth factors in psoriasis vulgaris. / Liew, Siaw Cheok; Das-Gupta, Esha; Chakravarthi, Srikumar; Wong, Shew Fung; Lee, Nagarajah; Safdar, Najeeb; Jamil, Adawiyah.

In: BMC Research Notes, Vol. 5, 201, 2012.

Research output: Contribution to journalArticle

Liew, Siaw Cheok ; Das-Gupta, Esha ; Chakravarthi, Srikumar ; Wong, Shew Fung ; Lee, Nagarajah ; Safdar, Najeeb ; Jamil, Adawiyah. / Differential expression of the angiogenesis growth factors in psoriasis vulgaris. In: BMC Research Notes. 2012 ; Vol. 5.
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AU - Safdar, Najeeb

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