Dietary phytochemicals activate the redox-sensitive transcription factor Nrf2

Nadia Salem Alrawaiq, Azman Abdullah

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nuclear transcription factor erythroid 2p45-related factor 2 (Nrf2) plays a crucial role in regulating phase-2 detoxifying/antioxidant gene induction. Under physiological conditions, NRF2 is mainly located in the cytoplasm. However, in response to oxidative stress, NRF2 translocates to the nucleus and binds to specific DNA sites, termed "antioxidant response elements" or "electrophile response elements," to initiate the transcription of numerous cytoprotective genes. Many structurally diverse antioxidants derived from various sources of dietary phytochemicals have been found to activate this particular redox-sensitive transcription factor, thereby potentiating the cellular detoxification action of Nrf2.This review focuses on known phytochemical inducers and the mechanism by which they regulate antioxidant responsive element (ARE)/Nrf2-dependent detoxification genes.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue number5
Publication statusPublished - 2014

Fingerprint

Phytochemicals
Antioxidant Response Elements
Oxidation-Reduction
Transcription Factors
Antioxidants
Genes
Cytoplasm
Oxidative Stress
DNA

Keywords

  • Dietary phytochemicals
  • Keap1
  • Nrf2
  • Phase 2 enzymes
  • Sulforaphane

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Dietary phytochemicals activate the redox-sensitive transcription factor Nrf2. / Alrawaiq, Nadia Salem; Abdullah, Azman.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, No. 5, 2014, p. 11-16.

Research output: Contribution to journalArticle

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