Dietary carbohydrate, fiber and sugar and risk of breast cancer according to menopausal status in Malaysia

Suhaina Sulaiman, Mohd Razif Shahril, Sharifah Wajihah Wafa, Soraya Hanie Shaharudin, Sharifah Noor Akmal Syed Hussin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Dietary carbohydrate, fiber and sugar intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Objective: To examine the association of premenopausal and postmenopausal breast cancer risk with dietary carbohydrate, fiber and sugar intake. Materials and Methods: This population based case-control study was conducted in Malaysia with 382 breast cancer patients and 382 controls. Food intake pattern was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders were included in analysis. Results: A significant two fold increased risk of breast cancer among premenopausal (OR Q4 to Q1=1.93, 95%CI: 1.53-2.61, p-trend=0.001) and postmenopausal (OR Q4 to Q1=1.87, 95%CI: 1.03-2.61, p-trend=0.045) women was observed in the highest quartile of sugar. A higher intake of dietary fiber was associated with a significantly lower breast cancer risk among both premenopausal (ORQ4 to Q1=0.31, 95%CI: 0.12-0.79, p-trend=0.009) and postmenopausal (ORQ4 to Q1=0.23, 95%CI: 0.07-0.76, p-trend=0.031) women. Conclusions: Sugar and dietary fiber intake were independently related to pre- and postmenopausal breast cancer risk. However, no association was observed for dietary carbohydrate intake.

Original languageEnglish
Pages (from-to)5959-5964
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume15
Issue number14
DOIs
Publication statusPublished - 2014

Fingerprint

Dietary Sucrose
Dietary Carbohydrates
Malaysia
Dietary Fiber
Breast Neoplasms
Confidence Intervals
Odds Ratio
Developed Countries
Case-Control Studies
Eating
Logistic Models
Interviews
Food
Incidence
Population

Keywords

  • Breast cancer
  • Carbohydrate
  • Fiber
  • Postmenopausal
  • Premenopausal
  • Sugar

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Dietary carbohydrate, fiber and sugar and risk of breast cancer according to menopausal status in Malaysia. / Sulaiman, Suhaina; Shahril, Mohd Razif; Wafa, Sharifah Wajihah; Shaharudin, Soraya Hanie; Hussin, Sharifah Noor Akmal Syed.

In: Asian Pacific Journal of Cancer Prevention, Vol. 15, No. 14, 2014, p. 5959-5964.

Research output: Contribution to journalArticle

Sulaiman, Suhaina ; Shahril, Mohd Razif ; Wafa, Sharifah Wajihah ; Shaharudin, Soraya Hanie ; Hussin, Sharifah Noor Akmal Syed. / Dietary carbohydrate, fiber and sugar and risk of breast cancer according to menopausal status in Malaysia. In: Asian Pacific Journal of Cancer Prevention. 2014 ; Vol. 15, No. 14. pp. 5959-5964.
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abstract = "Background: Dietary carbohydrate, fiber and sugar intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Objective: To examine the association of premenopausal and postmenopausal breast cancer risk with dietary carbohydrate, fiber and sugar intake. Materials and Methods: This population based case-control study was conducted in Malaysia with 382 breast cancer patients and 382 controls. Food intake pattern was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95{\%} confidence intervals (CI) and a broad range of potential confounders were included in analysis. Results: A significant two fold increased risk of breast cancer among premenopausal (OR Q4 to Q1=1.93, 95{\%}CI: 1.53-2.61, p-trend=0.001) and postmenopausal (OR Q4 to Q1=1.87, 95{\%}CI: 1.03-2.61, p-trend=0.045) women was observed in the highest quartile of sugar. A higher intake of dietary fiber was associated with a significantly lower breast cancer risk among both premenopausal (ORQ4 to Q1=0.31, 95{\%}CI: 0.12-0.79, p-trend=0.009) and postmenopausal (ORQ4 to Q1=0.23, 95{\%}CI: 0.07-0.76, p-trend=0.031) women. Conclusions: Sugar and dietary fiber intake were independently related to pre- and postmenopausal breast cancer risk. However, no association was observed for dietary carbohydrate intake.",
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AU - Sulaiman, Suhaina

AU - Shahril, Mohd Razif

AU - Wafa, Sharifah Wajihah

AU - Shaharudin, Soraya Hanie

AU - Hussin, Sharifah Noor Akmal Syed

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N2 - Background: Dietary carbohydrate, fiber and sugar intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Objective: To examine the association of premenopausal and postmenopausal breast cancer risk with dietary carbohydrate, fiber and sugar intake. Materials and Methods: This population based case-control study was conducted in Malaysia with 382 breast cancer patients and 382 controls. Food intake pattern was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders were included in analysis. Results: A significant two fold increased risk of breast cancer among premenopausal (OR Q4 to Q1=1.93, 95%CI: 1.53-2.61, p-trend=0.001) and postmenopausal (OR Q4 to Q1=1.87, 95%CI: 1.03-2.61, p-trend=0.045) women was observed in the highest quartile of sugar. A higher intake of dietary fiber was associated with a significantly lower breast cancer risk among both premenopausal (ORQ4 to Q1=0.31, 95%CI: 0.12-0.79, p-trend=0.009) and postmenopausal (ORQ4 to Q1=0.23, 95%CI: 0.07-0.76, p-trend=0.031) women. Conclusions: Sugar and dietary fiber intake were independently related to pre- and postmenopausal breast cancer risk. However, no association was observed for dietary carbohydrate intake.

AB - Background: Dietary carbohydrate, fiber and sugar intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Objective: To examine the association of premenopausal and postmenopausal breast cancer risk with dietary carbohydrate, fiber and sugar intake. Materials and Methods: This population based case-control study was conducted in Malaysia with 382 breast cancer patients and 382 controls. Food intake pattern was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders were included in analysis. Results: A significant two fold increased risk of breast cancer among premenopausal (OR Q4 to Q1=1.93, 95%CI: 1.53-2.61, p-trend=0.001) and postmenopausal (OR Q4 to Q1=1.87, 95%CI: 1.03-2.61, p-trend=0.045) women was observed in the highest quartile of sugar. A higher intake of dietary fiber was associated with a significantly lower breast cancer risk among both premenopausal (ORQ4 to Q1=0.31, 95%CI: 0.12-0.79, p-trend=0.009) and postmenopausal (ORQ4 to Q1=0.23, 95%CI: 0.07-0.76, p-trend=0.031) women. Conclusions: Sugar and dietary fiber intake were independently related to pre- and postmenopausal breast cancer risk. However, no association was observed for dietary carbohydrate intake.

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KW - Postmenopausal

KW - Premenopausal

KW - Sugar

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