Diagnostic value of the 13C methacetin breath test in various stages of chronic liver disease

Sanjiv Mahadeva, Hamizah Razlan, Nurhayaty Muhamad Marzuki, Mei Ling Sharon Tai, Shamsul Azhar Shah, Tze Zen Ong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The accuracy of the 13C-methacetin breath test ( 13C-MBT) in differentiating between various stages of liver disease is not clear. A cross-sectional study of Asian patients was conducted to examine the predictive value of the 13C-MBT in various stages of chronic liver diseases. Diagnostic accuracy of the breath test was determined by sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve analysis. Seventy-seven patients (47 men/30 women, mean age 50 16 years) were recruited. Forty-seven patients had liver cirrhosis (Child Pugh A = 11, Child Pugh B = 15, and Child Pugh C = 21), 21 had fibrosis, and 9 had chronic inflammation. The sensitivity and positive predictive value for liver fibrosis, cirrhosis (all stages), Child-Pugh A, Child-Pugh B, and Child-Pugh C were 65% and 56%, 89% and 89%, 67% and 42%, 40% and 40%, and 50% and 77%, respectively. Area under curve values for fibrosis was 0.62 (0.39-0.86), whilst that for cirrhosis (all stages) was 0.95 (0.91-0.99). The 13C-methacetin breath test has a poor predictive value for liver fibrosis but accurately determines advanced cirrhosis.

Original languageEnglish
Article number235796
JournalGastroenterology Research and Practice
DOIs
Publication statusPublished - 2011

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Breath Tests
Liver Diseases
Chronic Disease
Liver Cirrhosis
Fibrosis
Area Under Curve
methacetin
Cross-Sectional Studies
Inflammation
Sensitivity and Specificity

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Diagnostic value of the 13C methacetin breath test in various stages of chronic liver disease. / Mahadeva, Sanjiv; Razlan, Hamizah; Marzuki, Nurhayaty Muhamad; Tai, Mei Ling Sharon; Shah, Shamsul Azhar; Ong, Tze Zen.

In: Gastroenterology Research and Practice, 2011.

Research output: Contribution to journalArticle

Mahadeva, Sanjiv ; Razlan, Hamizah ; Marzuki, Nurhayaty Muhamad ; Tai, Mei Ling Sharon ; Shah, Shamsul Azhar ; Ong, Tze Zen. / Diagnostic value of the 13C methacetin breath test in various stages of chronic liver disease. In: Gastroenterology Research and Practice. 2011.
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