Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents

Janet Yeow Hua Hong, Muhammad Yazid Jalaludin, Bujang Mohamad Adam, Md Zain Fuziah, Loo Ling Wu, Rahmah Rasat, Harun Binti Fatimah, Supramaniam Premaa, Uma Ponnudurai, Haniff Jamaiyah

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Diabetic ketoacidosis (DKA) is a late presentation of newly diagnosed type 1 diabetes mellitus (DM) in children. The aim of this study was to determine the clinical characteristics of type 1 DM at presentation so that appropriate actions can be taken to promote early diagnosis. Methods: This was a retrospective cohort review from a patient registry database. Data on all patients younger than 20 years old diagnosed with type 1 DM who had been registered with the Malaysian Diabetes in Children and Adolescents Registry (DiCARE) from its inception in 2006 until 2009 were analysed. Results: The study included 490 children and adolescents, out of which 57.1% were female. The mean (SD) age at diagnosis was 7.5 (3.7) years, which increased from year 2000 to 2009 [6.6 (3.3) years to 9.6 (3.5) years; p = 0.001]. An increasing percentage of DKA at diagnosis was observed from year 2000 (54.5%) to year 2009 (66.7%), which remained high and leveled between 54.5% and 75.0%. DKA was more common in patients with normal weight (p = 0.002) with no significant association with age, gender, ethnicity and status of family history of diabetes mellitus. Conclusion: An increasing trend of age at diagnosis of patients with type 1 DM was observed. Besides that, proportion of DKA at diagnosis had remained high over the past decade. This study found that normal weight was associated with status of DKA, thus more detailed investigations are required to determine the risk factors for DKA.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalMalaysian Family Physician
Volume10
Issue number3
Publication statusPublished - 2016

Fingerprint

Diabetic Ketoacidosis
Type 1 Diabetes Mellitus
Registries
Weights and Measures
Early Diagnosis
Diabetes Mellitus
Databases

Keywords

  • Adolescents
  • Children
  • Diabetic ketoacidosis
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Family Practice
  • Community and Home Care

Cite this

Hong, J. Y. H., Jalaludin, M. Y., Mohamad Adam, B., Fuziah, M. Z., Wu, L. L., Rasat, R., ... Jamaiyah, H. (2016). Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents. Malaysian Family Physician, 10(3), 11-18.

Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents. / Hong, Janet Yeow Hua; Jalaludin, Muhammad Yazid; Mohamad Adam, Bujang; Fuziah, Md Zain; Wu, Loo Ling; Rasat, Rahmah; Fatimah, Harun Binti; Premaa, Supramaniam; Ponnudurai, Uma; Jamaiyah, Haniff.

In: Malaysian Family Physician, Vol. 10, No. 3, 2016, p. 11-18.

Research output: Contribution to journalArticle

Hong, JYH, Jalaludin, MY, Mohamad Adam, B, Fuziah, MZ, Wu, LL, Rasat, R, Fatimah, HB, Premaa, S, Ponnudurai, U & Jamaiyah, H 2016, 'Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents', Malaysian Family Physician, vol. 10, no. 3, pp. 11-18.
Hong JYH, Jalaludin MY, Mohamad Adam B, Fuziah MZ, Wu LL, Rasat R et al. Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents. Malaysian Family Physician. 2016;10(3):11-18.
Hong, Janet Yeow Hua ; Jalaludin, Muhammad Yazid ; Mohamad Adam, Bujang ; Fuziah, Md Zain ; Wu, Loo Ling ; Rasat, Rahmah ; Fatimah, Harun Binti ; Premaa, Supramaniam ; Ponnudurai, Uma ; Jamaiyah, Haniff. / Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents. In: Malaysian Family Physician. 2016 ; Vol. 10, No. 3. pp. 11-18.
@article{8c970f5fdefc4cd58ce4d5f5cdf094ea,
title = "Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents",
abstract = "Background: Diabetic ketoacidosis (DKA) is a late presentation of newly diagnosed type 1 diabetes mellitus (DM) in children. The aim of this study was to determine the clinical characteristics of type 1 DM at presentation so that appropriate actions can be taken to promote early diagnosis. Methods: This was a retrospective cohort review from a patient registry database. Data on all patients younger than 20 years old diagnosed with type 1 DM who had been registered with the Malaysian Diabetes in Children and Adolescents Registry (DiCARE) from its inception in 2006 until 2009 were analysed. Results: The study included 490 children and adolescents, out of which 57.1{\%} were female. The mean (SD) age at diagnosis was 7.5 (3.7) years, which increased from year 2000 to 2009 [6.6 (3.3) years to 9.6 (3.5) years; p = 0.001]. An increasing percentage of DKA at diagnosis was observed from year 2000 (54.5{\%}) to year 2009 (66.7{\%}), which remained high and leveled between 54.5{\%} and 75.0{\%}. DKA was more common in patients with normal weight (p = 0.002) with no significant association with age, gender, ethnicity and status of family history of diabetes mellitus. Conclusion: An increasing trend of age at diagnosis of patients with type 1 DM was observed. Besides that, proportion of DKA at diagnosis had remained high over the past decade. This study found that normal weight was associated with status of DKA, thus more detailed investigations are required to determine the risk factors for DKA.",
keywords = "Adolescents, Children, Diabetic ketoacidosis, Type 1 diabetes mellitus",
author = "Hong, {Janet Yeow Hua} and Jalaludin, {Muhammad Yazid} and {Mohamad Adam}, Bujang and Fuziah, {Md Zain} and Wu, {Loo Ling} and Rahmah Rasat and Fatimah, {Harun Binti} and Supramaniam Premaa and Uma Ponnudurai and Haniff Jamaiyah",
year = "2016",
language = "English",
volume = "10",
pages = "11--18",
journal = "Malaysian Family Physician",
issn = "1985-207X",
publisher = "Academy of Family Physicians of Malaysia",
number = "3",

}

TY - JOUR

T1 - Diabetic ketoacidosis at diagnosis of type 1 diabetes mellitus in Malaysian children and adolescents

AU - Hong, Janet Yeow Hua

AU - Jalaludin, Muhammad Yazid

AU - Mohamad Adam, Bujang

AU - Fuziah, Md Zain

AU - Wu, Loo Ling

AU - Rasat, Rahmah

AU - Fatimah, Harun Binti

AU - Premaa, Supramaniam

AU - Ponnudurai, Uma

AU - Jamaiyah, Haniff

PY - 2016

Y1 - 2016

N2 - Background: Diabetic ketoacidosis (DKA) is a late presentation of newly diagnosed type 1 diabetes mellitus (DM) in children. The aim of this study was to determine the clinical characteristics of type 1 DM at presentation so that appropriate actions can be taken to promote early diagnosis. Methods: This was a retrospective cohort review from a patient registry database. Data on all patients younger than 20 years old diagnosed with type 1 DM who had been registered with the Malaysian Diabetes in Children and Adolescents Registry (DiCARE) from its inception in 2006 until 2009 were analysed. Results: The study included 490 children and adolescents, out of which 57.1% were female. The mean (SD) age at diagnosis was 7.5 (3.7) years, which increased from year 2000 to 2009 [6.6 (3.3) years to 9.6 (3.5) years; p = 0.001]. An increasing percentage of DKA at diagnosis was observed from year 2000 (54.5%) to year 2009 (66.7%), which remained high and leveled between 54.5% and 75.0%. DKA was more common in patients with normal weight (p = 0.002) with no significant association with age, gender, ethnicity and status of family history of diabetes mellitus. Conclusion: An increasing trend of age at diagnosis of patients with type 1 DM was observed. Besides that, proportion of DKA at diagnosis had remained high over the past decade. This study found that normal weight was associated with status of DKA, thus more detailed investigations are required to determine the risk factors for DKA.

AB - Background: Diabetic ketoacidosis (DKA) is a late presentation of newly diagnosed type 1 diabetes mellitus (DM) in children. The aim of this study was to determine the clinical characteristics of type 1 DM at presentation so that appropriate actions can be taken to promote early diagnosis. Methods: This was a retrospective cohort review from a patient registry database. Data on all patients younger than 20 years old diagnosed with type 1 DM who had been registered with the Malaysian Diabetes in Children and Adolescents Registry (DiCARE) from its inception in 2006 until 2009 were analysed. Results: The study included 490 children and adolescents, out of which 57.1% were female. The mean (SD) age at diagnosis was 7.5 (3.7) years, which increased from year 2000 to 2009 [6.6 (3.3) years to 9.6 (3.5) years; p = 0.001]. An increasing percentage of DKA at diagnosis was observed from year 2000 (54.5%) to year 2009 (66.7%), which remained high and leveled between 54.5% and 75.0%. DKA was more common in patients with normal weight (p = 0.002) with no significant association with age, gender, ethnicity and status of family history of diabetes mellitus. Conclusion: An increasing trend of age at diagnosis of patients with type 1 DM was observed. Besides that, proportion of DKA at diagnosis had remained high over the past decade. This study found that normal weight was associated with status of DKA, thus more detailed investigations are required to determine the risk factors for DKA.

KW - Adolescents

KW - Children

KW - Diabetic ketoacidosis

KW - Type 1 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=84979248477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979248477&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84979248477

VL - 10

SP - 11

EP - 18

JO - Malaysian Family Physician

JF - Malaysian Family Physician

SN - 1985-207X

IS - 3

ER -